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Titolo:
Donepezil in the treatment of opioid-induced sedation: Report of six cases
Autore:
Slatkin, NE; Rhiner, M; Bolton, TM;
Indirizzi:
City Hope Natl Med Ctr, Dept Support Care & Palliat Med, Duarte, CA 91010 USA City Hope Natl Med Ctr Duarte CA USA 91010 liat Med, Duarte, CA 91010 USA
Titolo Testata:
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
fascicolo: 5, volume: 21, anno: 2001,
pagine: 425 - 438
SICI:
0885-3924(200105)21:5<425:DITTOO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED RESPIRATORY DEPRESSION; PONTINE RETICULAR-FORMATION; DESYNCHRONIZED SLEEP SIGNS; PLACEBO-CONTROLLED TRIAL; INTRATHECAL NEOSTIGMINE; ALZHEIMERS-DISEASE; CANCER PAIN; POSTOPERATIVE ANALGESIA; BASAL FOREBRAIN; ACETYLCHOLINE-RELEASE;
Keywords:
donepezil; wakefulness; cholinesterase inhibitors; arousal; analgesics; opioid; hypersomnia; narcotic/adverse effects; acetylcholine; central nervous system stimulants;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
119
Recensione:
Indirizzi per estratti:
Indirizzo: Slatkin, NE City Hope Natl Med Ctr, Dept Support Care & Palliat Med, 1500 E Duarte Rd,Duarte, CA 91010 USA City Hope Natl Med Ctr 1500 E Duarte Rd Duarte CA USA 91010 SA
Citazione:
N.E. Slatkin et al., "Donepezil in the treatment of opioid-induced sedation: Report of six cases", J PAIN SYMP, 21(5), 2001, pp. 425-438

Abstract

Donepezil, an oral acetylcholinesterase inhibitor approved for the treatment of Alzheimer's disease, was given to 6 cancer pain patients having sedation related to the analgesic use of opioids. Each patient was taking more than 200 mg of oral morphine equivalent per day, and several were receiving complex analgesic regiments consisting of multiple adjuvant medications. Sedation improved at least moderately in 5 of the patients and mildly in 1 after they began taking donepezil. Patients reported a decrease in episodes of spontaneous sleeping during the day, fewer myoclonic twitches, improved daily function and greater social interaction. Several also reported improved improved sleep at night. Analgesia was not compromised by the use of donepezil, and in some cases it appeared improved. Donepezil may be a valuable alternative to psychostimulants in the treatment of opioid-induced sedation. A prospective controlled trial comparing the treatment effects of psychostimulants and donepezil on patients having opioid-induced sedation is underway. (C) U.S. Cancer Pain Relief Committee, 2001.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:16:38