Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Review of the outcome of management of Graves' disease in children and adolescents
Autore:
Bergman, P; Auldist, A; Cameron, F;
Indirizzi:
Royal Childrens Hosp, Dept Surg, Parkville, Vic 3052, Australia Royal Childrens Hosp Parkville Vic Australia 3052 le, Vic 3052, Australia Royal Childrens Hosp, Ctr Hormone Res, Dept Endocrinol & Diabet, Parkville, Vic 3052, Australia Royal Childrens Hosp Parkville Vic Australia 3052 le, Vic 3052, Australia
Titolo Testata:
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
fascicolo: 2, volume: 37, anno: 2001,
pagine: 176 - 182
SICI:
1034-4810(200104)37:2<176:ROTOOM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIOIODINE TREATMENT; THYROTROPIN RECEPTOR; PEDIATRIC-PATIENTS; ANTITHYROID DRUG; HYPERTHYROIDISM; THERAPY; CHILDHOOD; THYROTOXICOSIS; EXPERIENCE; THYROXINE;
Keywords:
adolescence; childhood; Graves' disease; paediatric hyperthyroidism; subtotal thyroidectomy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Bergman, P Monash Med Ctr, Dept Paediat, Clayton Campus,246 Clayton Rd, Clayton, Vic 3168, Australia Monash Med Ctr Clayton Campus,246 Clayton Rd Clayton Vic Australia 3168
Citazione:
P. Bergman et al., "Review of the outcome of management of Graves' disease in children and adolescents", J PAEDIAT C, 37(2), 2001, pp. 176-182

Abstract

Objective: To review our recent experience in the management of paediatricGraves' disease. the leading cause of hyper thyroidism in childhood, in view of ongoing international debate regarding therapy. Methodology: Retrospective medical record review of patients with Graves' disease, treated between 1985 and 1999, at the Royal Children's Hospital, Melbourne. Results: Forty patients, aged at diagnosis between 2.9 and 17.6 years (median age 11 years: 31 females), were treated. Thirty-three patients receivedeither definitive therapy or at least 24 months medical therapy and followup at the time of the study. Six patients experienced successful remissionupon withdrawal of medication (median medication duration 3.2 years: four females; median follow up 4.1 years). Children successfully achieving remission were younger at presentation than those requiring surgery (9.5 vs 12.9years, respectively; P = 0.01). Ten patients were treated surgically, leaving 4-6 g residual thyroid tissue. Surgical indications included failed initial medical therapy, relapse after medication cessation, noncompliance andsignificant medication side effects. During a median follow up of 1.7 years (range 0.2-5 years), three of 10 patients have subsequently relapsed and four of 10 patients are receiving postoperative thyroxine replacement. Transient hypocalcaemia occurred in five patients and temporary recurrent laryngeal nerve palsy occurred in two patients. Conclusions: Fewer than 20% of children experienced successful sustained remission at median follow up of 3.2 years. Medication remains a well-tolerated therapeutic option. Surgery is a reasonable alternative when there are specific indications, In order to decrease the likelihood of surgical relapse, less than 4 g thyroid tissue should be left postoperatively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:46:22