Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Burkholderia cepacia in cystic fibrosis: Novel Australian cluster strain without accelerated respiratory deterioration
Autore:
Fitzgerald, DA; Cooper, DM; Paul, M; Tiley, S; Kado, J; Cordwell, J; Collins, C;
Indirizzi:
John Hunter Childrens Hosp, Dept Resp Med, Newcastle, NSW, Australia John Hunter Childrens Hosp Newcastle NSW Australia astle, NSW, Australia
Titolo Testata:
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
fascicolo: 2, volume: 37, anno: 2001,
pagine: 130 - 136
SICI:
1034-4810(200104)37:2<130:BCICFN>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSEUDOMONAS-CEPACIA; COLONIZATION; INFECTION; EPIDEMIOLOGY; MALTOPHILIA; CRITERIA; WEIGHT;
Keywords:
cystic fibrosis; Burkholderia cepacia; FEV1; growth; nutrition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Fitzgerald, DA Childrens Hosp, Dept Resp Med, Locked Bag 4001, Westmead, NSW 2145, Australia Childrens Hosp Locked Bag 4001 Westmead NSW Australia 2145
Citazione:
D.A. Fitzgerald et al., "Burkholderia cepacia in cystic fibrosis: Novel Australian cluster strain without accelerated respiratory deterioration", J PAEDIAT C, 37(2), 2001, pp. 130-136

Abstract

Objective: To determine whether 4 years of colonization with a novel Australian cluster strain (The 'Hunter' strain) of Burkholderia cepacia (B, cepacia) in cystic fibrosis (CF) patients was associated with more rapid decline in nutritional status and pulmonary function than in non-colonized contemporaries from the same CF clinic. Methodology: A retrospective review of respiratory function and nutritional data from a single multidisciplinary paediatric CF clinic over 4 years (1993-97). Results: Paired spirometry data for 1993 and 1997 were available in 47 patients without (n = 31) and with B, cepacia (n = 16) colonization (mean (+/-SD) ages in 1993: 12.1 years Ir 4.0 vs 12.6 years +/- 6.5; P = 0.83). Their percentage predicted forced expiratory volume in 1 s (FEV1) (94.2% +/- 16.7 vs 85.9% +/- 21.2; P = 0.19) were not significantly different. The averaged annual fall in FEV1 over 4 years was also not significantly different (3.8% +/- 3.8 vs 3.6% +/- 3.7; P = 0.82). Weight percentile (Wt%), height percentile (Ht%) and percentage age weight for height (%WFH) were not significantly different between groups in 1993. By 1997, Wt% (36.7% +/- 25.1 vs 22.3% +/- 19.6: P = 0.04) and Ht% (42.5% +/- 29.6 vs 17.6% +/- 19.4; P = 0.002) but not %WFH (102% +/- 10.0 vs 106% +/- 11.2: P > 0.10) were lower in subjects with B, cepacia. Conclusions: in adolescent CF patients, colonization with the Hunter strain of B. cepacia was associated with a deterioration in some nutritional parameters but not with an accelerated decline in FEV1 over 4 years. As varying pathogenicity of B. cepacia strains may account for differing rates of pulmonary decline, further assessment of the consequences of colonization with certain strains of B. cepacia in CF is needed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:32:12