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Titolo:
Expression of stimulator of Fe transport is not enhanced in Hfe knockout mice
Autore:
Knutson, MD; Levy, JE; Andrews, NC; Wessling-Resnick, M;
Indirizzi:
Harvard Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA Harvard Sch Publ Hlth Boston MA USA 02115 Dept Nutr, Boston, MA 02115 USA Howard Hughes Med Inst, Boston, MA 02115 USA Howard Hughes Med Inst Boston MA USA 02115 Med Inst, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pediat, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA Harvard Univ BostonMA USA 02115 Sch Med, Dept Med, Boston, MA 02115 USA Brigham & Womens Hosp, Div Hematol, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 v Hematol, Boston, MA 02115 USA Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 iv Hematol Oncol, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF NUTRITION
fascicolo: 5, volume: 131, anno: 2001,
pagine: 1459 - 1464
SICI:
0022-3166(200105)131:5<1459:EOSOFT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFERRIN RECEPTOR EXPRESSION; HEREDITARY HEMOCHROMATOSIS; IRON OVERLOAD; BOUND IRON; LIVER; MOUSE; GENE; BRAIN; MUTATION; FERRITIN;
Keywords:
stimulator of Fe transport; HFE; hemochromatosis; brain; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Wessling-Resnick, M Harvard Sch Publ Hlth, Dept Nutr, Bldg 2,Room 205,665 Huntingdon Ave, Boston, MA 02115 USA Harvard Sch Publ Hlth Bldg 2,Room 205,665 Huntingdon Ave Boston MA USA 02115
Citazione:
M.D. Knutson et al., "Expression of stimulator of Fe transport is not enhanced in Hfe knockout mice", J NUTR, 131(5), 2001, pp. 1459-1464

Abstract

Hfe knockout (-/-) mice recapitulate many of the biochemical abnormalitiesof hereditary hemochromatosis (HH), but the molecular mechanisms involved in the etiology of iron overload in HH remain poorly understood. It was found previously that livers of patients with HH contained 5-fold higher SFT (stimulator of Fe transport) mRNA levels relative to subjects without HH, Because this observation suggests a possible role for SFT in HH, we investigated SFT mRNA expression in Hfe(-/-) mice. The 4- and 10-wk-old Hfe(-/-) mice do not have elevated levels of hepatic SFT transcripts relative to age-matched Hfe(-/-) mice, despite having 2.2- and 3.3-fold greater hepatic nonheme iron concentrations, respectively. Northern blot analyses of various mouse tissues revealed that SFT is widely expressed. The novel observation that SFT transcripts are abundant in brain prompted a comparison of SFT transcript levels and nonheme iron levels in the brains of Hfe(+/+) and Hfe(-/-) mice. Neither SFT mRNA levels nor nonheme iron levels differed between groups. Further comparisons of Hfe(-/-) and Hfe(+/+) mouse tissues revealed no significant differences in SFT mRNA levels in duodenum, the site of increased iron absorption in HH, Important distinctions between Hfe(-/-) mice and HH patients include not only differences in the relative rate and magnitudeof iron loading but also the lack of fibrosis and phlebotomy treatment in the knockout animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 09:42:57