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Titolo:
Experimental and clinical evaluation of iterative reconstruction (OSEM) indynamic PET: Quantitative characteristics and effects on kinetic modeling
Autore:
Boellaard, R; van Lingen, A; Lammertsma, AA;
Indirizzi:
Univ Hosp Vrije Univ, Clin PET Ctr, NL-1007 MB Amsterdam, Netherlands UnivHosp Vrije Univ Amsterdam Netherlands NL-1007 MB erdam, Netherlands
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 5, volume: 42, anno: 2001,
pagine: 808 - 817
SICI:
0161-5505(200105)42:5<808:EACEOI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BAYESIAN IMAGE-RECONSTRUCTION; WHOLE-BODY PET; POSITRON-EMISSION-TOMOGRAPHY; MEDIAN ROOT PRIOR; ECAT EXACT HR+; PERFORMANCE EVALUATION; ATTENUATION CORRECTION; EM ALGORITHM; GIBBS PRIORS; RESOLUTION;
Keywords:
iterative reconstruction; dynamic PET; quantitative accuracy; kinetic modeling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Boellaard, R Univ Hosp Vrije Univ, Clin PET Ctr, POB 7057, NL-1007 MB Amsterdam, Netherlands Univ Hosp Vrije Univ POB 7057 Amsterdam Netherlands NL-1007 MB
Citazione:
R. Boellaard et al., "Experimental and clinical evaluation of iterative reconstruction (OSEM) indynamic PET: Quantitative characteristics and effects on kinetic modeling", J NUCL MED, 42(5), 2001, pp. 808-817

Abstract

The purpose of this study was to investigate the quantitative properties and effects of ordered-subset expectation maximization (OSEM) on kinetic modeling compared with filtered backprojection (FBP) in dynamic PET studies. Both phantom and patient studies were performed. Methods: For phantom studies dynamic two-dimensional emission scans with 10-min frames and 20-min scanintervals were acquired over a 14-h period using an HR+ PET scanner. Various phantoms were scanned: 2-, 5-, 10-, and 20-cm-diameter phantoms filled with an F-18 solution (300 kBq/ml) and a NEMA phantom filled with an F-18 background (40 kBq/ml) and a cold or C-11 insert (450 kBq/ml). Transmission (Tx) scans of 5-60 min were acquired. Data were reconstructed using FBP Hanning 0.5 and OSEM with 2-12 iterations and 12 or 24 subsets. Quantitative accuracy and noise characteristics were assessed. For patient studies, five cardiac, three oncologic, and three brain dynamic F-18-FDG scans were used. Five reconstructions were performed: FBP Hanning 0.5, and OSEM 2 x 12 and OSEM 4 x 16 with and without 5-mm full width at half maximum smoothing. Time-activity curves were calculated using volumes of interest. The input function was derived from arterial sampling. Metabolic rate of glucose (MRglu) was calculated with a standard two-tissue compartment model and Patlak analysis. Results: Contribution of Tx noise to the reconstructed image was smaller for OSEM than for FBP. Differences in signal-to-noise ratio between FBP and OSEM depended on number of iterations and phantom size, Bias with OSEM was observed for regions enclosed within a 5- to 10-fold hotter background. For cardiac studies OSEM 2 x 12 and OSEM 4 x 16 resulted in 13% and 21% higher pixel values and 9% and 15% higher MRglu values compared with FBP. Smoothing decreased all these values to 2%, Similar results were found for most tumor studies. For brain studies MRglu of FBP and OSEM 4 x 16 agreed within 2%. Use of OSEM image-derived input functions for cardiac PET studies resulted in a decrease in calculated MRglu of about 15%. Conclusion: For mostPET studies OSEM has equal quantitative accuracy as FBP. The higher pixel and MRglu values are explained by the better resolution of OSEM. However, OSEM does not provide accurate image-derived input functions for FDG cardiacPET studies because of bias in regions located within a hotter background.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:38:12