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Titolo:
In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson's disease
Autore:
Murai, T; Muller, U; Werheid, K; Sorger, D; Reuter, M; Becker, T; von Cramon, DY; Barthel, H;
Indirizzi:
Max Planck Inst Cognit Neurosci, Leipzig, Germany Max Planck Inst Cognit Neurosci Leipzig Germany rosci, Leipzig, Germany Univ Leipzig, Dept Psychiat, D-7010 Leipzig, Germany Univ Leipzig Leipzig Germany D-7010 pt Psychiat, D-7010 Leipzig, Germany Univ Leipzig, Dept Cognit Neurol, D-7010 Leipzig, Germany Univ Leipzig Leipzig Germany D-7010 gnit Neurol, D-7010 Leipzig, Germany Univ Leipzig, Dept Nucl Med, D-7010 Leipzig, Germany Univ Leipzig Leipzig Germany D-7010 pt Nucl Med, D-7010 Leipzig, Germany Neurol Clin Martha Maria, Halle, Germany Neurol Clin Martha Maria Halle Germany lin Martha Maria, Halle, Germany
Titolo Testata:
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
fascicolo: 2, volume: 13, anno: 2001,
pagine: 222 - 228
SICI:
0895-0172(200121)13:2<222:IVEFDA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-123 BETA-CIT; MDMA ECSTASY USERS; HUMAN BRAIN; MONOAMINE TRANSPORTERS; BINDING-KINETICS; SPECT; DEPRESSION; IODINE-123-BETA-CIT; 2-BETA-CARBOMETHOXY-3-BETA-(4-IODOPHENYL)TROPANE; TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Murai, T Kyoto Univ, Fac Med, Dept Psychiat, Shogoin Kawaharacho 54, Kyoto6068507,Japan Kyoto Univ Shogoin Kawaharacho 54 Kyoto Japan 6068507 8507,Japan
Citazione:
T. Murai et al., "In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson's disease", J NEUROP CL, 13(2), 2001, pp. 222-228

Abstract

Parkinson's disease affects various neurotransmitter systems. Using SPECT,the authors measured [I-123]beta -CIT binding ratios of the caudate, putamen, medial thalamus, and dorsal midbrain over cerebellum in 16 patients with Parkinson's disease, and examined con correlations with clinical ratings. Whereas striatal binding ratios (reflecting regional dopamine transporter densities) were associated with motor symptoms, dorsal midbrain binding ratios (reflecting regional serotonin transporter densities) were significantly correlated with the mentation, behavior, and mood subscale of the UnifiedParkinson's Disease Rating Scale. These findings indicate that degeneration of the nigrostriatal dopaminergic neurons and a dysfunctional serotonergic raphe system contribute differentially to motor deficits and neuropsychiatric symptoms in Parkinson's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:58:33