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Titolo:
Development of a resonator with automatic tuning and coupling capability to minimize sample motion noise for in vivo EPR spectroscopy
Autore:
He, GL; Petryakov, S; Samouilov, A; Chzhan, M; Kuppusamy, P; Zweier, JL;
Indirizzi:
Johns Hopkins Univ, Sch Med, EPR Ctr, Baltimore, MD 21224 USA Johns Hopkins Univ Baltimore MD USA 21224 PR Ctr, Baltimore, MD 21224 USA Johns Hopkins Univ, Sch Med, Dept Med, Div Cardiol, Baltimore, MD 21224 USA Johns Hopkins Univ Baltimore MD USA 21224 ardiol, Baltimore, MD 21224 USA
Titolo Testata:
JOURNAL OF MAGNETIC RESONANCE
fascicolo: 2, volume: 149, anno: 2001,
pagine: 218 - 227
SICI:
1090-7807(200104)149:2<218:DOARWA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOOP-GAP RESONATOR; BIOLOGICAL SAMPLES; BEATING HEART; FREE-RADICALS; FIELD;
Keywords:
in vivo EPR; varactor diode; automatic tuning; automatic coupling; spin label;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: He, GL Johns Hopkins Univ, Sch Med, EPR Ctr, 5501 Hopkins Bayview Circle, Baltimore, MD 21224 USA Johns Hopkins Univ 5501 Hopkins Bayview Circle Baltimore MD USA 21224
Citazione:
G.L. He et al., "Development of a resonator with automatic tuning and coupling capability to minimize sample motion noise for in vivo EPR spectroscopy", J MAGN RES, 149(2), 2001, pp. 218-227

Abstract

EPR spectroscopy has been applied to measure free radicals in vivo; however respiratory, cardiac, and other movements of Living animals are a major source of noise and spectral distortion. Sample motions result in changes inresonator frequency, Q, and coupling. These instabilities limit the applications that can be performed and the quality of data that can be obtained. Therefore, it is of great importance to develop resonators with automatic tuning and automatic coupling capability. We report the development of automatic tuning and automatic coupling provisions for a 750-MHz transversely oriented electric field reentrant resonator using two electronically tunable high Q hyperabrupt varactor diodes and feedback loops. In both moving phantoms and living mice, these automatic coupling control and automatic tuning control provisions resulted in an 8- to 10-fold increase in signal-to-noiseratio. (C) 2001 Academic Press.

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Documento generato il 06/04/20 alle ore 01:04:11