Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Vertical transmission of multidrug-resistant human immunodeficiency virus type 1 (HIV-1) and continued evolution of drug resistance in an HIV-1-infected infant
Autore:
Johnson, VA; Petropoulos, CJ; Woods, CR; Hazelwood, JD; Parkin, NT; Hamilton, CD; Fiscus, SA;
Indirizzi:
Univ Alabama, Sch Med, Div Infect Dis, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 Infect Dis, Birmingham, AL 35294 USA Vet Affairs Med Ctr, Birmingham, AL USA Vet Affairs Med Ctr Birmingham ALUSA ffairs Med Ctr, Birmingham, AL USA ViroLogic, S San Francisco, CA USA ViroLogic S San Francisco CA USAViroLogic, S San Francisco, CA USA Wake Forest Univ, Winston Salem, NC 27109 USA Wake Forest Univ Winston Salem NC USA 27109 , Winston Salem, NC 27109 USA Duke Univ, Med Ctr, Durham, NC USA Duke Univ Durham NC USADuke Univ, Med Ctr, Durham, NC USA Univ N Carolina, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USAUniv N Carolina, Chapel Hill, NC USA
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 11, volume: 183, anno: 2001,
pagine: 1688 - 1693
SICI:
0022-1899(20010601)183:11<1688:VTOMHI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERINATAL TRANSMISSION; INFECTED WOMEN; ZIDOVUDINE; REDUCTION; THERAPY; COHORT; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, VA Univ Alabama, Sch Med, Div Infect Dis, THT 229,1530 3rd Ave S,Birmingham,AL 35294 USA Univ Alabama THT 229,1530 3rd Ave S Birmingham AL USA 35294 SA
Citazione:
V.A. Johnson et al., "Vertical transmission of multidrug-resistant human immunodeficiency virus type 1 (HIV-1) and continued evolution of drug resistance in an HIV-1-infected infant", J INFEC DIS, 183(11), 2001, pp. 1688-1693

Abstract

To confirm the vertical transmission of multidrug-resistant (MDR) human immunodeficiency virus type 1 (HIV-1) and to assess its impact on further evolution of drug-resistant virus in an infant, proviral DNA amplified from infected peripheral blood mononuclear cell cultures was sequenced to identifyreverse transcriptase (RT) and protease (PR) mutations. The infant had proviral DNA with evidence of RT mutations (M41L, L74V, and T215Y) and 3 PR substitutions (K20R, M36I, and V82A). After delivery, the mother's proviral DNA had the same substitutions. Phylogenetic analyses of these HIV-1 RT and PR sequences indicated epidemiological linkage. Plasma drug susceptibility was determined by using a recombinant virus assay. Plasma HIV-1 obtained after the infant's birth demonstrated reduced susceptibility to zidovudine and ritonavir. Thus, vertical transmission of MDR HIV-1 was demonstrated in the setting of detectable maternal plasma viremia. Further accumulation of broad MDR in the infant's virus to 3 antiretroviral classes occurred, despite postnatal therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:28:03