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Titolo:
Apolipoprotein B, ratio of total cholesterol to HDL-C, and blood pressure in abdominally obese white and black American women
Autore:
Okosun, IS; Choi, S; Hash, R; Dever, GEA;
Indirizzi:
Mercer Univ, Sch Med, Dept Community Med, Macon, GA 31207 USA Mercer UnivMacon GA USA 31207 d, Dept Community Med, Macon, GA 31207 USA
Titolo Testata:
JOURNAL OF HUMAN HYPERTENSION
fascicolo: 5, volume: 15, anno: 2001,
pagine: 299 - 305
SICI:
0950-9240(200105)15:5<299:ABROTC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; ISCHEMIC-HEART-DISEASE; INSULIN-RESISTANCE SYNDROME; HIGH-DENSITY-LIPOPROTEIN; FAT DISTRIBUTION; UNITED-STATES; A-I; WAIST CIRCUMFERENCE; VISCERAL OBESITY; NATIONAL-HEALTH;
Keywords:
blood pressure; abdominal obesity; ApoB; HDL-C; LDL-C; total cholesterol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Okosun, IS Mercer Univ, Sch Med, Dept Community Med, 1550 Coll St, Macon, GA 31207 USA Mercer Univ 1550 Coll St Macon GA USA 31207 Macon, GA 31207 USA
Citazione:
I.S. Okosun et al., "Apolipoprotein B, ratio of total cholesterol to HDL-C, and blood pressure in abdominally obese white and black American women", J HUM HYPER, 15(5), 2001, pp. 299-305

Abstract

Objective: To compare the association of apolipoprotein a (ApoB) and totalcholesterol to high-density lipoprotein cholesterol (TC/HDL) with blood pressure in abdominally obese white and black American women. We also sought to determine if there are ethnic differences in blood pressure values that could be explained by differences in mean values of ApoB and TC/HDL,Methods: Data (n = 1844) from the Third US National Health and Nutrition Examination Survey were used in this study. Abdominal obesity was defined aswaist circumference (WC) of greater than or equal to 88 cm or having WC greater than what was expected as predicted from residuals obtained from linear regression of WC on BMI, Bi-variate Pearson's correlation analysis was used to quantify the degree of association of ApoB and TC/HDL with blood pressure and other lipids. Multiple linear regression analysis was used to assess the independent contribution of ApoB and TC/HDL to blood pressure, adjusting for age, total cholesterol, alcohol intake, and smoking. To determineethnic differences in blood pressure values associated with ApoB or TC/HDL, dummy variables were used to compare blacks with whites fitted in multiple regression models, while adjusting for age, total cholesterol, alcohol intake and smoking. Results: Elevated ApoB was positively associated with diastolic and systolic blood pressure (DBP/SBP) in blacks and whites, independent of age, totalcholesterol, alcohol intake and smoking (P < 0.01). Elevated TC/HDL was also positively associated with increased DBP and SEP in whites (P < 0.05), For the same value of ApoB and TC/HDL whites had higher values of DBP and SEP than blacks, adjusting for confounding variables. Conclusions: Compared with TC/HDL, ApoB was more strongly associated with DBP and SEP in both abdominally obese white and black women. Since ApoB is associated with hypertension, the combination of elevated ApoB and hypertension may identify a group of patients with more marked risk of vascular disease, thus, warranting further investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 11:51:38