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Titolo:
Apoptosis and liver diseases: Recent concepts of mechanism and significance
Autore:
Ockner, RK;
Indirizzi:
Univ Calif San Francisco, Ctr Liver, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Div Gastroenterol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
fascicolo: 3, volume: 16, anno: 2001,
pagine: 248 - 260
SICI:
0815-9319(200103)16:3<248:AALDRC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; CYTOCHROME-C RELEASE; VIRUS CORE PROTEIN; PERMEABILITY TRANSITION PORE; ADENINE-NUCLEOTIDE TRANSLOCATOR; MITOCHONDRIAL RESPIRATORY-CHAIN; ALPHA-MEDIATED APOPTOSIS; ELECTRON-TRANSPORT CHAIN; DEPENDENT ANION CHANNEL;
Keywords:
AMP-activated protein kinase; Bcl-2; caspase; cell proliferation; cytochrome c; fatty acids; intermediate filaments; mitochondria; NF kappa B; oxidative stress;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
148
Recensione:
Indirizzi per estratti:
Indirizzo: Ockner, RK Univ Calif San Francisco, Ctr Liver, 513 Parnassus Ave,Room S-357, San Francisco, CA 94143 USA Univ Calif San Francisco 513 Parnassus Ave,Room S-357 San Francisco CA USA 94143
Citazione:
R.K. Ockner, "Apoptosis and liver diseases: Recent concepts of mechanism and significance", J GASTR HEP, 16(3), 2001, pp. 248-260

Abstract

Apoptosis, or programmed cell death, is a highly conserved mechanism that plays an essential role in numerous normal developmental and regulatory processes and disease states. It is mediated by a variable interaction among several components of the cell, including cell surface death receptors, the caspase cascade, mitochondrial metabolism and energetics, and the cytoskeleton. Even in those instances in which cell surface death receptors play a role, mitochondria are often central to the process, not only in mediating the death program, but in initiating it as well. In regard to mitochondrial involvement, a key role is hypothesized for an interaction among AMP-activated protein kinase, cytoskeletal intermediate filaments, and mitochondrial oxidation of fatty acids. This proposed interaction may be a critical element in the pathogenesis of intramitochondrial oxidative stress, diminished inner membrane potential (Delta psi (m),), and other mitochondrial changes that contribute to cell death. Apoptosis may participate in a wide variety of disease processes, ranging from chemical and physical injury to viral infection and cancer, but its mechanistic and functional relationship to theseconditions remains incompletely understood. Despite this, an understandingof the mechanisms involved and of the identity of potential pharmacologic targets is increasing, and warrants an optimistic view of their potential for clinical application. (C) 2001 Blackwell Science Asia Pry Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:54:51