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Titolo:
New directions and challenges in electrochemistry - Bioelectrochemistry atmetal/water interfaces
Autore:
Guidelli, R; Aloisi, G; Becucci, L; Dolfi, A; Moncelli, MR; Buoninsegni, FT;
Indirizzi:
Univ Florence, Dept Chem, I-50121 Florence, Italy Univ Florence FlorenceItaly I-50121 Dept Chem, I-50121 Florence, Italy
Titolo Testata:
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
fascicolo: 1, volume: 504, anno: 2001,
pagine: 1 - 28
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACE-PLASMON RESONANCE; SOLID SUPPORTED MEMBRANES; BILAYER-LIPID-MEMBRANES; SELF-ASSEMBLED MONOLAYERS; CYTOCHROME-C-OXIDASE; ORGANIZED MOLECULAR ASSEMBLIES; GRAMICIDIN CHANNEL FUNCTION; ELECTRON-TRANSFER REACTIONS; PHOSPHOLIPID MONOLAYERS; MERCURY-ELECTRODES;
Keywords:
membrane-covered electrode; bioelectrochemistry; electrified interface;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
131
Recensione:
Indirizzi per estratti:
Indirizzo: Guidelli, R Univ Florence, Dept Chem, Via G Capponi 9, I-50121 Florence, Italy Univ Florence Via G Capponi 9 Florence Italy I-50121 e, Italy
Citazione:
R. Guidelli et al., "New directions and challenges in electrochemistry - Bioelectrochemistry atmetal/water interfaces", J ELEC CHEM, 504(1), 2001, pp. 1-28

Abstract

Some aspects of bioelectrochemistry at metal \ water interfaces which may provide useful information on the role played by biomolecules in biologicalprocesses are overviewed and assessed. Electrochemical reactions of water-soluble redox proteins, either immobilized on bare or functionalized electrode surfaces or free to diffuse toward the electrode, are briefly reviewed. The preparation and architecture of metal-supported biomembrane models, both noncovalently and covalently attached to the metal surface, are described. The structure of self-organized phospholipid monolayers interposed between the metal surface and the aqueous phase is examined, with particular regard to the ionizable groups and the surface dipole potential of their polarheads. Particular attention is focused on the preparation of biomembrane models capable of incorporating integral proteins in a functionally active state. The use of experimental models of biomembranes for investigating the function of integral proteins, either incorporated in biomembrane fragmentsor proteoliposomes adsorbed on metal-supported mixed alkanethiol \ lipid bilayers, or directly incorporated in metal-supported lipid bilayers, is described. The potential of metal-supported lipid bilayers with a hydrophilic 'spacer' interposed between the metal surface and the bilayer for fundamental studies on the function of integral proteins and for reliable and rapid drug screening is emphasized. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 22:43:52