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Titolo:
Optimal dosing with risperidone: Updated recommendations
Autore:
Williams, R;
Indirizzi:
Univ British Columbia, Dept Psychiat, Vancouver, BC V5Z 1M9, Canada Univ British Columbia Vancouver BC Canada V5Z 1M9 ver, BC V5Z 1M9, Canada
Titolo Testata:
JOURNAL OF CLINICAL PSYCHIATRY
fascicolo: 4, volume: 62, anno: 2001,
pagine: 282 - 289
SICI:
0160-6689(200104)62:4<282:ODWRUR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
D2-DOPAMINE RECEPTOR OCCUPANCY; SCHIZOPHRENIC-PATIENTS; BIPOLAR DISORDER; HALOPERIDOL; OLANZAPINE; SYMPTOMS; DEMENTIA; PLACEBO; TRIAL; D-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, R Royal Jubilee Hosp, Dept Psychiat, 1900 Ft St, Victoria, BC V8R 4Z3, Canada Royal Jubilee Hosp 1900 Ft St Victoria BC Canada V8R 4Z3 anada
Citazione:
R. Williams, "Optimal dosing with risperidone: Updated recommendations", J CLIN PSY, 62(4), 2001, pp. 282-289

Abstract

Background: Drug dosages utilized during controlled clinical trials are not always optimal for patients encountered in day-to-day practice. The original trials of risperidone, a novel antipsychotic, suggested that an initialtarget dose of 6 mg/day was appropriate, but these trials were necessarilyconducted among patients who were chronically impaired, hospitalized, and often partly drug resistant. Data Sources: Relevant data relating to the dosage of risperidone identified through an online (MEDLINE) search using the keywords risperidone, schizophrenia, schizoaffective disorder, der,2erltin, bipolar disorder and dose were supplemented by a review of international and U.S. Congress abstracts in which the dose of risperidone was specifically described. Conclusion: On the basis of naturalistic studies, clinical audit, phase 4 trials, positron emission tomography data, and 5 years of clinical experience, the currently recommended target dose of risperidone is 4 mg/day for most patients, with less-rapid titration than previously recommended. Moreover, a lower dose than this and slower titration may be appropriate for elderly patients, young patients, and first-episode patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:24:22