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Titolo:
In vivo evidence for the role of lipoprotein lipase activity in the regulation of apolipoprotein AI metabolism: A kinetic study in control subjects and patients with type II diabetes mellitus
Autore:
Frenais, R; Nazih, H; Ouguerram, K; Maugeais, C; Zair, Y; Bard, JM; Charbonnel, B; Magot, T; Krempf, M;
Indirizzi:
Hotel Dieu, Clin Endocriniennes Malad Metab & Nutr, F-44093 Nantes 01, France Hotel Dieu Nantes France 01 alad Metab & Nutr, F-44093 Nantes 01, France Hotel Dieu, INSERM U 539, Human Nutr Res Ctr, F-44093 Nantes, France HotelDieu Nantes France F-44093 an Nutr Res Ctr, F-44093 Nantes, France
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 5, volume: 86, anno: 2001,
pagine: 1962 - 1967
SICI:
0021-972X(200105)86:5<1962:IVEFTR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; POSTHEPARIN PLASMA-LIPOPROTEIN; INSULIN-DEPENDENT DIABETICS; FRACTIONAL CATABOLIC RATE; ADIPOSE-TISSUE; STABLE-ISOTOPE; HEPATIC LIPASE; FAMILIAL HYPERTRIGLYCERIDEMIA; TRIGLYCERIDE-METABOLISM; CHOLESTEROL LEVELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Krempf, M Hotel Dieu, Clin Endocriniennes Malad Metab & Nutr, 1 Pl A Ricordeau, F-44093 Nantes 01, France Hotel Dieu 1 Pl A Ricordeau Nantes France 01 Nantes 01, France
Citazione:
R. Frenais et al., "In vivo evidence for the role of lipoprotein lipase activity in the regulation of apolipoprotein AI metabolism: A kinetic study in control subjects and patients with type II diabetes mellitus", J CLIN END, 86(5), 2001, pp. 1962-1967

Abstract

The aim of this study was to delineate the role of lipoprotein lipase (LPL) activity in the kinetic alterations of high density lipoprotein (HDL) metabolism in patients with type II diabetes mellitus compared with controls. The kinetics of HDL were studied by endogenous labeling of HDL apolipoprotein AI (HDL-apo AI) using a primed infusion of D-3-leucine. The HDL-apo AI fractional catabolic rate (FCR) was significantly increased (0.32 +/- 0.07 vs. 0.23 +/- 0.05 pool/day; P < 0.01), and HDL composition was changed [HDL cholesterol, 0.77 +/- 0.16 vs. 1.19 +/- 0.37 mmol/L (P < 0.05); HDL triglycerides, 0.19, 0.12 vs. 0.10 <plus/minus> 0.03 mmol/L (P < 0.05)] in diabetic patients compared with healthy subjects. HDL-apo AI FCR was correlated toplasma and HDL triglyceride concentrations (r = 0.82; P < 0.05 and r = 0.80; P < 0.05, respectively) and to homeostasis model assessment (r = 0.78; P< 0.05). Postheparin plasma LPL activity was decreased in type II diabetes(6.8 +/- 2.8 us. 18.1 +/- 5.2 mu mol/mL postheparin plasma h; P < 0.005) compared with that in healthy subjects and was correlated to the FCR of HDL-apo AI (r = -0.63; P < 0.05). LPL activity was also correlated with HDL cholesterol(r = 0.78; P < 0.05), plasma and HDL triglycerides (r = -0.87; P < 0.005 and r = -0.83; P < 0.05, respectively), and homeostasis model assessment (r = -0.79; P < 0.05). In addition, the LPL to hepatic lipase ratio wascorrelated with the catabolic rate of HDL(r = -0.76; P <less than> 0.06). These results suggest that a decrease in the LPL to hepatic lipase ratio intype II diabetes mellitus, mainly related to lowered LPL activity, could induce an increase in HDL catabolism. These alterations in HDL kinetics in type II diabetes proceed to some extent from changes in their composition, probably linked to an increase in triglyceride transfer from very low density lipoprotein particles, in close relationship with LPL activity and resistance to insulin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:26:32