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Titolo:
Preoperative oral rofecoxib does not decrease postoperative pain or morphine consumption in patients after radical prostatectomy: A prospective, randomized, double-blinded, placebo-controlled trial
Autore:
Huang, JJ; Taguchi, A; Hsu, HP; Andriole, GL; Kurz, A;
Indirizzi:
Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Anesthesiol, St Louis, MO 63110 USA
Titolo Testata:
JOURNAL OF CLINICAL ANESTHESIA
fascicolo: 2, volume: 13, anno: 2001,
pagine: 94 - 97
SICI:
0952-8180(200103)13:2<94:PORDND>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; CYCLOOXYGENASE-2; ANALGESIA; INHIBITOR; KETOROLAC; MODEL;
Keywords:
COX-II inhibitors; postoperative pain; prostatectomy; rofecoxib;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Huang et al., "Preoperative oral rofecoxib does not decrease postoperative pain or morphine consumption in patients after radical prostatectomy: A prospective, randomized, double-blinded, placebo-controlled trial", J CLIN ANES, 13(2), 2001, pp. 94-97

Abstract

Study Objective: To evaluate the analgesic efficacy of the rofecoxib po before radical prostatectomy. Design: Prospective, randomized double-blinded, placebo-controlled trial. Setting: Teaching hospital. Patients: Anesthetic management was standardized, Patients received eithera 50-mg rofecoxib capsule or a placebo capsule po I hour before induction of anesthesia. Measurements and Main Results: Patient-generated IO-cm visual analog scale(VAS) scores for pain were assessed at I, 2, 4, 6, 8, and 24 hours after surgery. Morphine consumption runs recorded from a patient-controlled analgesia device at the same time. A patient-generated overall pain relief score was obtained at 24 hours after surgery. We were unable to detect any differences between study groups with respect to postoperative morphine consumption, VAS score, or overall pain relief score. Conclusions: When rofecoxib is used po in maximum recommended doses beforesurgery, it does not provide significant analgesia that results in reduction in pain scores or analgesic requirements for patients after radical prostatectomy. (C) 2001 by Elsevier Science Inc.

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Documento generato il 04/07/20 alle ore 11:55:59