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Titolo:
Chromatin and cancer: Causes and consequences
Autore:
Singh, H; Sekinger, EA; Gross, DS;
Indirizzi:
Louisiana State Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Shreveport, LA 71130 USA Louisiana State Univ Shreveport LA USA 71130 ol, Shreveport, LA 71130 USA
Titolo Testata:
JOURNAL OF CELLULAR BIOCHEMISTRY
, , anno: 2000, supplemento:, 35
pagine: 61 - 68
SICI:
0730-2312(2000):<61:CACCAC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-SHOCK GENE; HISTONE DEACETYLASE; DNA METHYLATION; TRANSCRIPTIONAL REPRESSION; RAR-ALPHA; PROMOTER; BINDING; HETEROCHROMATIN; EXPRESSION; LEUKEMIA;
Keywords:
chromatin remodeling; transcriptional activators; DNA methylation; nuclear structure; leukemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Gross, DS Louisiana State Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Shreveport, LA 71130 USA Louisiana State Univ Shreveport LA USA 71130 port, LA 71130 USA
Citazione:
H. Singh et al., "Chromatin and cancer: Causes and consequences", J CELL BIOC, 2000, pp. 61-68

Abstract

In this review, we discuss recent evidence implicating chromatin structurein the etiology of cancer. In particular, we present evidence indicating that inappropriate regulation of chromatin structure inhibits normal cell differentiation pathways and stimulates uncontrolled cell proliferation, withthe outcome being oncogenesis. Such inappropriate chromatin structures arise as a consequence of (i) chromosomal rearrangements that fuse gene-specific activators with global co-regulators, drastically altering activator function; (ii) hypermethylation of tumor suppressor gene promoters, resulting in their inactivation; or (iii) mistargeted nuclear compartmentalization ofgrowth-control genes and their regulators, resulting in the up- or down-regulation of such genes. How does chromatin silence genes? Recent results From model in vivo systems argues that chromatin can repress transcription attwo levels: (i) by sterically interfering with tl-re binding of transcription factors to the promoter, thereby blocking initiation; and (ii) at a step subsequent to the binding of activators and recruitment of the preinitiation complex. Published 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:40:45