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Titolo:
The M-1 receptor is required for muscarinic activation of mitogen-activated protein (MAP) kinase in murine cerebral cortical neurons
Autore:
Hamilton, SE; Nathanson, NM;
Indirizzi:
Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Pharmacol, Seattle, WA 98195 USA
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 19, volume: 276, anno: 2001,
pagine: 15850 - 15853
SICI:
0021-9258(20010511)276:19<15850:TMRIRF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; TISSUE-SPECIFIC REGULATION; ACETYLCHOLINE-RECEPTOR; CHICK HEART; LINKED RECEPTORS; CELLS; GENE; PATHWAY; SECRETION; PIRENZEPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Nathanson, NM Univ Washington, Sch Med, Dept Pharmacol, POB 357750, Seattle, WA 98195 USA Univ Washington POB 357750 Seattle WA USA 98195 WA 98195 USA
Citazione:
S.E. Hamilton e N.M. Nathanson, "The M-1 receptor is required for muscarinic activation of mitogen-activated protein (MAP) kinase in murine cerebral cortical neurons", J BIOL CHEM, 276(19), 2001, pp. 15850-15853

Abstract

Muscarinic acetylcholine receptors (mAChR) in the central nervous system are involved in learning and memory, epileptic seizures, and processing the amyloid precursor protein. The M-1 receptor is the predominant ntAChR subtype in the cortex and hippocampus. Although the five mAChR fall into two broad functional groups, all five subtypes, when expressed in recombinant systems, can activate the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway has been implicated in learning and memory, amyloid protein processing, and neuronal plasticity. We used M-1 knock-out mice to determine the role of this receptor subtype in signal transduction in the mouse forebrain, In primary cortical cultures from mice lacking the M-1 mAChR, agonist-stimulated phosphoinositide hydrolysis was reduced by more than 60% compared with cultures from wild type mice. Although muscarinic agonists induced robust activation of MAPK in cortical cultures from wild type mice, mAChR-mediated activation of MAPK was virtually absent in cultures from M-1-deficient mice. These results indicate that the M-1, mAChR is the major subtype that mediates activation of phospholipase C and MAPK in mouse forebrain.

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Documento generato il 27/11/20 alle ore 06:49:39