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Titolo:
Cyclin D1 represses STAT3 activation through a Cdk4-independent mechanism
Autore:
Bienvenu, F; Gascan, H; Coqueret, O;
Indirizzi:
CHU Angers, INSERM, EMI U 9928, F-49033 Angers, France CHU Angers AngersFrance F-49033 ERM, EMI U 9928, F-49033 Angers, France
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 20, volume: 276, anno: 2001,
pagine: 16840 - 16847
SICI:
0021-9258(20010518)276:20<16840:CDRSAT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CYCLE; ESTROGEN-RECEPTOR; TRANSCRIPTIONAL ACTIVATION; GENE-EXPRESSION; V-SRC; INHIBITION; KINASE; G1; PHOSPHORYLATION; TRANSFORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Coqueret, O CHU Angers, INSERM, EMI U 9928, 4 Rue Larrey, F-49033 Angers, France CHU Angers 4 Rue Larrey Angers France F-49033 Angers, France
Citazione:
F. Bienvenu et al., "Cyclin D1 represses STAT3 activation through a Cdk4-independent mechanism", J BIOL CHEM, 276(20), 2001, pp. 16840-16847

Abstract

STAT3 transcription factors are cytoplasmic proteins that induce gene activation in response to cytokine receptor stimulation. Following tyrosine phosphorylation, STAT3 proteins dimerize, translocate into the nucleus, and activate specific target genes. Activation is transient, and down-regulation of STAT3 signaling occurs within a few hours. In this study, we show that cyclin D1 inhibits STAT3 activation. In co-immunoprecipitation and pull-downassays, cyclin D1 was found to associate with the activation domain of STAT3 upon interleukin-6 stimulation. Overexpression of cyclin D1 inhibited transcriptional activation by STAT3 proteins. This effect was not shared by cyclin E, was independent of association with Cdk4, and was unaffected by inhibitors of Cdk4, Whereas cyclin D1 had no effect on the steady-state levelof STAT3 proteins in the cytoplasm, it was found to reduce the STAT3 nuclear level in HepG2 cells. These results suggest a model by which cyclin D1 is part of a feedback network controlling the down-regulation of STAT3 activity and highlight a new activity for this cell cycle regulatory protein.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 11:10:06