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Titolo:
From infection to autoimmunity
Autore:
Fairweather, D; Kaya, Z; Shellam, GR; Lawson, CM; Rose, NR;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Pathol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 mmunol, Baltimore, MD 21205 USA Univ Western Australia, Dept Microbiol, Perth, WA 6009, Australia Univ Western Australia Perth WA Australia 6009 Perth, WA 6009, Australia Murdoch Univ, Div Vet & Biomed Sci, Perth, WA, Australia Murdoch Univ Perth WA Australia v Vet & Biomed Sci, Perth, WA, Australia
Titolo Testata:
JOURNAL OF AUTOIMMUNITY
fascicolo: 3, volume: 16, anno: 2001,
pagine: 175 - 186
SICI:
0896-8411(200105)16:3<175:FITA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; MURINE CYTOMEGALOVIRUS-INFECTION; DECAY-ACCELERATING FACTOR; STREPTOCOCCAL-M-PROTEIN; TUMOR-NECROSIS-FACTOR; RESISTANT B10.A MICE; COBRA VENOM FACTOR; NK CELLS; INNATE IMMUNITY; T-CELLS;
Keywords:
autoimmunity; innate immunity; myocarditis; review;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
98
Recensione:
Indirizzi per estratti:
Indirizzo: Rose, NR Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USAJohns Hopkins Univ Baltimore MD USA 21205 altimore, MD 21205 USA
Citazione:
D. Fairweather et al., "From infection to autoimmunity", J AUTOIMMUN, 16(3), 2001, pp. 175-186

Abstract

We have investigated two models of virally-induced autoimmune myocarditis in mice using widely different infectious agents. Infection of susceptible BALB/c mice with either Coxsackievirus or murine cytomegalovirus results inthe development of acute myocarditis from day 7-14 after infection, and chronic myocarditis from day 28 onwards. The chronic phase of myocarditis is associated with mononuclear infiltration of the myocardium and the production of autoantibodies to cardiac myosin, although infectious virus cannot bedetected past day 14 of infection. T cells and autoantibodies have been shown to be important for the development of autoimmune myocarditis. Many researchers have investigated the role of molecular mimicry in the developmentof myocarditis after viral infection. This review explores the 'adjuvant' effect of infection on the innate immune response and how this determines the progression to autoimmune disease. We show that NK cells protect againstthe development of disease, while complement and complement receptors are involved in the development of autoimmune myocarditis induced by inoculation with virus or cardiac myosin, respectively. Our results suggest that the innate immune response to viral and self-antigens may determine whether susceptible strains of mice progress to chronic autoimmune disease. These findings have broad implications for understanding the role of infection in inducing autoimmune disease. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:51:43