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Titolo:
Epidemiology of human longevity: The search for appropriate methodology
Autore:
Gavrilov, LA; Gavrilova, NS;
Indirizzi:
Univ Chicago, Ctr Aging, NORC, Chicago, IL 60637 USA Univ Chicago ChicagoIL USA 60637 Ctr Aging, NORC, Chicago, IL 60637 USA
Titolo Testata:
JOURNAL OF ANTI-AGING MEDICINE
fascicolo: 1, volume: 4, anno: 2001,
pagine: 13 - 30
SICI:
1094-5458(200121)4:1<13:EOHLTS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETICALLY COMPLEX TRAITS; PATERNAL AGE; SPONTANEOUS MUTATION; OSTEOGENESIS IMPERFECTA; DROSOPHILA-MELANOGASTER; CALORIC RESTRICTION; LINKAGE STRATEGIES; OLDER FATHERS; BIRTH-DEFECTS; RISK FACTOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
200
Recensione:
Indirizzi per estratti:
Indirizzo: Gavrilov, LA Univ Chicago, Ctr Aging, NORC, 1155 E 60th St, Chicago, IL 60637 USA Univ Chicago 1155 E 60th St Chicago IL USA 60637 IL 60637 USA
Citazione:
L.A. Gavrilov e N.S. Gavrilova, "Epidemiology of human longevity: The search for appropriate methodology", J ANTI-AG M, 4(1), 2001, pp. 13-30

Abstract

In contrast to the remarkable progress in genetics of aging of such animalmodels as yeast, nematodes, and Drosophila, little is known about mechanisms that control human longevity. The main obstacle in human studies is thatthe opportunities for direct experiments with humans are limited and therefore data collection through observations, i.e., epidemiological methods, are particularly important. To advance scientific knowledge in this area, itis also important to broaden the arsenal of concepts and methods for humanlongevity studies and to develop alternative tactics to cope with environmental and social confounding. To cope with environmental and social confounding, this paper suggests two robust exploratory tests with low risk of artifactual results, based on the analysis of two kinds of genetic influences on human longevity: (1) parental consanguinity, which increases the proportion of homozygotes in offspring, leading to the expression of recessive traits and an increased incidence of multifactorial traits (via increased variance for genetic liability distribution); and (2) advanced paternal age at conception, which is known to be one of the major sources of new mutations in human populations. This paper also describes methodologies to study the role of environmental factors (shared familial environment and early seasonal events) as determinants of human longevity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:09:29