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Titolo:
Patterns of response to repeated total sleep deprivations in depression
Autore:
Wiegand, MH; Lauer, CJ; Schreiber, W;
Indirizzi:
Tech Univ Munich, Dept Psychiat & Psychotherapy, D-8000 Munich, Germany Tech Univ Munich Munich Germany D-8000 hotherapy, D-8000 Munich, Germany Klin Angermuhle, Deggendorf, Germany Klin Angermuhle Deggendorf GermanyKlin Angermuhle, Deggendorf, Germany Univ Marburg, Dept Psychiat & Psychotherapy, Marburg, Germany Univ Marburg Marburg Germany Psychiat & Psychotherapy, Marburg, Germany
Titolo Testata:
JOURNAL OF AFFECTIVE DISORDERS
fascicolo: 2-3, volume: 64, anno: 2001,
pagine: 257 - 260
SICI:
0165-0327(200105)64:2-3<257:PORTRT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR DEPRESSION; AMITRIPTYLINE; COMBINATION; NAPS;
Keywords:
total sleep deprivation; repeated sleep deprivations; major depression; amitriptyline; antidepressant therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Wiegand, MH Tech Univ Munich, Dept Psychiat & Psychotherapy, D-8000 Munich, Germany Tech Univ Munich Munich Germany D-8000 -8000 Munich, Germany
Citazione:
M.H. Wiegand et al., "Patterns of response to repeated total sleep deprivations in depression", J AFFECT D, 64(2-3), 2001, pp. 257-260

Abstract

Background: Patterns of response and nonresponse in repeated sleep deprivation (SD) are of both clinical and scientific interest, as yet, studies have yielded inconsistent results. Methods: Eighteen inpatients suffering froma major depression were subjected to a series of six scheduled total sleepdeprivations within 3 weeks; 12 of them completed the whole protocol. All were under a constant antidepressant medication with amitriptyline. SD effects were measured using observer and self rating scales. Results: Each single SD led to a significant improvement. Of the 12 patients who completed the protocol, seven were classified as responders at endpoint (i.e., 1 week after the sixth TSD). The majority of patients exhibited a pattern of responses and nonresponses randomly distributed over time. Ther e was no temporaltrend. The initial effect did not predict the average response to the following SDs. Limitations: One third of patients dropped out before completingthe protocol which limits the scope of the study. Conclusions: Response toa single SD is not generalizable on a series of following SDs in an individual. Thr mechanism of action of SD does probably not involve mechanisms subjected to habituation or sensitization. (C) 2001 Elsevier Science B.V. Allrights reserved.

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Documento generato il 08/04/20 alle ore 12:11:38