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Titolo:
The effects of tryptophan depletion on mood and psychiatric symptoms
Autore:
Van der Does, AJW;
Indirizzi:
Leiden Univ, Dept Psychol, NL-2333 AK Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2333 AK NL-2333 AK Leiden, Netherlands Leiden Univ, Dept Psychiat, NL-2333 AK Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2333 AK NL-2333 AK Leiden, Netherlands
Titolo Testata:
JOURNAL OF AFFECTIVE DISORDERS
fascicolo: 2-3, volume: 64, anno: 2001,
pagine: 107 - 119
SICI:
0165-0327(200105)64:2-3<107:TEOTDO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEASONAL AFFECTIVE-DISORDER; FREE DEPRESSED-PATIENTS; SEROTONIN REUPTAKE INHIBITORS; MAJOR AFFECTIVE-DISORDER; HEALTHY-HUMAN SUBJECTS; NEUTRAL AMINO-ACIDS; PLASMA TRYPTOPHAN; RAPID DEPLETION; ANTIDEPRESSANT ACTION; NORMAL VOLUNTEERS;
Keywords:
tryptophan depiction; mood; psychiatric symptoms; depression; relapse; cognition;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Van der Does, AJW Leiden Univ, Dept Psychol, Wassenaarseweg 52, NL-2333 AKLeiden, Netherlands Leiden Univ Wassenaarseweg 52 Leiden Netherlands NL-2333 AK
Citazione:
A.J.W. Van der Does, "The effects of tryptophan depletion on mood and psychiatric symptoms", J AFFECT D, 64(2-3), 2001, pp. 107-119

Abstract

Background: The number of studies using tryptophan depletion (TD) challenge has increased markedly in the past few years. Recently, a number or negative results have been published, implicating that the effect of TD on mood may be less consistent than previously thought. Methods: The literature on the mood effects of TD in psychiatric patients and healthy volunteers was reviewed. Results: TD has a mood-lowering effect in subgroups of recovered depressed patients, patients with seasonal affective disorder and vulnerablehealthy subjects. The mood effect in former patients is of a different quality, however, than the effect in healthy subjects. Some recent negative studies in depression might be explained by insufficient lowering of plasma tryptophan levels. Preliminary evidence exists for an effect of TD on bulimia nervosa, autism, aggression and substance dependence. Conclusions: The effects of TD on mood may be more consistent than suggested by a number of recent negative studies. Response to TD in recovered depressed patients is associated with prior treatment. However, even in SSRI-treated patients the relapse rates are not higher than 50-60%, which needs to be explained. The clinical usefulness of the response to TD in recovered patients (prediction of relapse after treatment discontinuation) and in symptomatic patients (prediction of treatment refactoriness) deserves more research attention. Further suggestions for future research include the cognitive effects of TD in recovered depressed patients and the effect of dietary habits on response to TD. (C) 2001 Elsevier Science B;V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:39:12