Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Impulse oscillometry in healthy nonsmokers and asymptomatic smokers: Effects of bronchial challenge with methacholine
Autore:
Kohlhaufl, M; Brand, P; Scheuch, G; Schulz, H; Haussinger, K; Heyder, J;
Indirizzi:
GSF, Inst Inhalat Biol, Clin Res Grp Aerosols Med, Gauting, Germany GSF Gauting Germany t Biol, Clin Res Grp Aerosols Med, Gauting, Germany
Titolo Testata:
JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
fascicolo: 1, volume: 14, anno: 2001,
pagine: 1 - 12
SICI:
0894-2684(200121)14:1<1:IOIHNA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
FORCED-OSCILLATION TECHNIQUE; NONSPECIFIC AIRWAY HYPERRESPONSIVENESS; WORKING PARTY STANDARDIZATION; EUROPEAN RESPIRATORY SOCIETY; RANDOM NOISE; OFFICIAL STATEMENT; PROVOCATION TESTS; COLD AIR; IMPEDANCE; RESISTANCE;
Keywords:
impulse oscillation; respiratory impedance; respiratory resistance; respiratory reactance; healthy subjects; methacholine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Kohlhaufl, M Fachklin Munchen Gauting, Zentrum Pneumol & Thoraxchirurg, Robert Koch Allee 2, D-82131 Gauting, Germany Fachklin Munchen Gauting RobertKoch Allee 2 Gauting Germany D-82131
Citazione:
M. Kohlhaufl et al., "Impulse oscillometry in healthy nonsmokers and asymptomatic smokers: Effects of bronchial challenge with methacholine", J AEROSOL M, 14(1), 2001, pp. 1-12

Abstract

The clinical application of respiratory impedance measurements by oscillation techniques for monitoring bronchial challenge testing is hampered by the fact that data in healthy nonsmokers and asymptomatic smokers are very limited. The objective of this study was to analyze the changes in impedance to a methacholine provocation test in healthy nonsmokers and asymptomatic smokers, and to investigate whether smokers show a different response compared to nonsmokers. The response to methacholine challenge was assessed by impulse oscillometry (IOS) (resistance A and reactance X at 5, 10, 15, 20, 25, and 35 Hz) and spirometry (FEV1, MEF50) in 105 healthy subjects (55 nonsmokers: "NS"; 50 asymptomatic smokers: "S") in whom the provocation dose of 2.44 mg methacholine did not result in a fall of FEV1 below 20% predicted of the baseline value. The baseline reactance X values of S were significantly lower compared to NS from 10 to 35 Hz (p less than or equal to 0.01), whereas S and NS did not differ in resistance A over the whole frequency spectrum from 5 to 35 Hz. S showed a significantly higher mean baseline resonant frequency X(f(0)); i.e., the frequency at which inertial forces are equaland opposite to elastic forces, compared to NS (NS: X(f(0)) = 10.8 +/- 2.9Hz; S = 12.6 +/- 4.0 Hz, p = 0.01). In both groups methacholine challenge resulted in an increase in X (f) especially at 5 and 10 Hz, and a marked decrease in X(f) over the whole frequency spectrum. In S a significantly higher decrease of postchallenge X-5Hz and X-10Hz was measured compared to NS (NS: DeltaX((5Hz)) = -0.044 +/- 0.003; S: DeltaX((5Hz)) = -0.083 +/- 0.013; p = 0.0017. NS: DeltaX((10Hz)) = -0.050 +/- 0.001; S: DeltaX((10Hz)) = -0.082 +/- 0.017; p = 0.008). R and X at low frequencies showed a three to fourtimes higher postchallenge reaction compared to FEV1. Pre- and postchallenge FEV1 did not correlate with resistance A (f) and reactance X(f) over thewhole frequency spectrum. In S perchallenge X(f) values from 10 to 35 HZ were significantly lower, and postchallenge decrease of X-5Hz and X-10Hz values were significantly higher compared to that of NS, whereas pre- and postchallenge A(f) values were similar in both groups. These results can be explained by changes in the elastic properties of the lung induced by a diffuse subclinical respiratory bronchiolitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 14:54:04