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Titolo:
Cardiovascular effects caused by rapid administration of gadoversetamide injection in anesthetized dogs
Autore:
Wible, JH; Galen, KP; Wojdyla, JK;
Indirizzi:
Mallinckrodt Imaging, St Louis, MO USA Mallinckrodt Imaging St Louis MO USA linckrodt Imaging, St Louis, MO USA
Titolo Testata:
INVESTIGATIVE RADIOLOGY
fascicolo: 5, volume: 36, anno: 2001,
pagine: 292 - 298
SICI:
0020-9996(200105)36:5<292:CECBRA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GADOPENTETATE DIMEGLUMINE; BOLUS INJECTION; GADODIAMIDE INJECTION; CONTRAST-MEDIA; GD-DTPA; RATS; MULTICENTER; VOLUNTEERS; PATHOLOGY; EFFICACY;
Keywords:
magnetic resonance; contrast media; gadolinium; power injection; cardiovascular function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Wible, JH Mallinckrodt Inc, 675 McDonnell Blvd,POB 5840, St Louis, MO 63134 USA Mallinckrodt Inc 675 McDonnell Blvd,POB 5840 St Louis MO USA 63134
Citazione:
J.H. Wible et al., "Cardiovascular effects caused by rapid administration of gadoversetamide injection in anesthetized dogs", INV RADIOL, 36(5), 2001, pp. 292-298

Abstract

RATIONALE AND OBJECTIVES. This study assessed the cardiovascular effects of gadoversetamide and other gadolinium chelates administered at high rates of injection. METHODS, Anesthetized beagles were instrumented to record the electrocardiogram and to measure arterial blood pressure. In part 1, each animal was injected with gadoversetamide at rates of 1.0, 3.0, and 10 mL/s, In part 2, each animal was injected with gadoversetamide, gadopentetate dimeglumine, gadodiamide, and gadoteridol at a dose of 0.6 mmol/kg delivered at a rate of 3.0 mL/s,RESULTS, Intravenous administration of gadoversetamide caused transient decreases in both heart rate and blood pressure. The rate of injection did not affect the magnitude of the heart rate or blood pressure changes, Administration of gadoversetamide, gadopentetate dimeglumine, and gadodiamide elicited equivalent changes in cardiovascular function. Injection of gadoteridol caused a similar degree of hypotension, but the changes lasted longer. CONCLUSIONS. Rapid administration of gadoversetamide caused no potentiation in cardiovascular changes. Our data support the initiation of a clinical trial to demonstrate the safety of rapidly administering gadoversetamide with the use of a power injector.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:28:10