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Titolo:
Autoimmune neutropenia with cyclic oscillation of neutrophil count after steroid administration
Autore:
Hirase, N; Abe, Y; Muta, K; Ishikura, H; Umemura, T; Nawata, H; Nishimura, J;
Indirizzi:
Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Fukuoka 812, Japan Kyushu Univ Fukuoka Japan 812 ed & Bioregulatory Sci, Fukuoka 812, Japan Aso Iizuka Hosp, Dept Internal Med, Fukuoka, Japan Aso Iizuka Hosp Fukuoka Japan a Hosp, Dept Internal Med, Fukuoka, Japan Kyushu Univ, Sch Hlth Sci, Dept Med Technol, Fukuoka, Japan Kyushu Univ Fukuoka Japan ch Hlth Sci, Dept Med Technol, Fukuoka, Japan Kyushu Univ, Med Inst Bioregulat, Dept Clin Immunol, Oita, Japan Kyushu Univ Oita Japan Inst Bioregulat, Dept Clin Immunol, Oita, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF HEMATOLOGY
fascicolo: 3, volume: 73, anno: 2001,
pagine: 346 - 350
SICI:
0925-5710(200104)73:3<346:ANWCOO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIBODIES;
Keywords:
autoimmune neutropenia; cyclic neutropenia; antineutrophil antibody; prednisolone; splenectomy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Hirase, N Natl Kokura Hosp, Dept Internal Med, 10-1 Harugaoka,Kokuraminamiku, Kitakyushu, Fukuoka 8020803, Japan Natl Kokura Hosp 10-1 Harugaoka,Kokuraminamiku Kitakyushu Fukuoka Japan 8020803
Citazione:
N. Hirase et al., "Autoimmune neutropenia with cyclic oscillation of neutrophil count after steroid administration", INT J HEMAT, 73(3), 2001, pp. 346-350

Abstract

A 16-year-old female patient was evaluated for pancytopenia. She had a white blood cell count of 1.6 x 10(9)/L with 0.02 neutrophils and a platelet count of 19 x 10(9)/L. In the bone marrow, mature granulocytes were markedlydecreased in number, but no atypical cells were present. Antineutrophil antibody was demonstrated by flow cytometry, and the level of platelet-associated immunoglobulin G was increased. A diagnosis of autoimmune neutropenia and thrombocytopenia was made. Interestingly, neutrophil and platelet counts fluctuated cyclically after the initiation of prednisolone therapy. The neutrophil count fluctuated between 0.1 x 10(9)/L and 7 x 10(9)/L, and the platelet count fluctuated between 19 x 10(9)/L and 175 x 10(9)/L, in I-week cycles. Following splenectomy, neutrophil and platelet counts normalized. We believe the immune mechanism of recurrent neutropenia in this patient differs from that in other patients with cyclic neutropenia reported with stemcell disorders. (C) 2001 The Japanese Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:36:17