Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Growth deceleration and bone metabolism in nutritional dwarfing rats
Autore:
Friedman, SM; Gamba, CA; Boyer, PM; Guglielmotti, MB; Vacas, MI; Rodriguez, PN; Guerrero, C; Lifshitz, F;
Indirizzi:
Univ Buenos Aires, Fac Dent, Dept Biochem, Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina Buenos Aires, DF, Argentina Univ Buenos Aires, Fac Dent, Dept Physiol, Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina Buenos Aires, DF, Argentina Univ Buenos Aires, Fac Dent, Dept Oral Pathol, Buenos Aires, DF, ArgentinaUniv Buenos Aires Buenos Aires DF Argentina Buenos Aires, DF, Argentina Miami Childrens Hosp, Chief Staff, Miami, FL USA Miami Childrens Hosp Miami FL USA drens Hosp, Chief Staff, Miami, FL USA
Titolo Testata:
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
fascicolo: 3, volume: 52, anno: 2001,
pagine: 225 - 233
SICI:
0963-7486(200105)52:3<225:GDABMI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBOPTIMAL NUTRITION; GLA-PROTEIN; WEIGHT-GAIN; FOOD-INTAKE; CHILDREN; ADAPTATION; HORMONE; OBESITY; MARKER; ENERGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Friedman, SM Univ Buenos Aires, Fac Dent, Dept Biochem, Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina , DF, Argentina
Citazione:
S.M. Friedman et al., "Growth deceleration and bone metabolism in nutritional dwarfing rats", INT J F S N, 52(3), 2001, pp. 225-233

Abstract

Nutritional status as well as energy and protein intake are critical regulators of IGF-1 and IGFBP-3 and contribute to the modulation of bone remodeling and formation. The purpose of this study was to investigate on an experimental model with nutritional dwarfing (ND), whether the alterations on body growth velocity, energy metabolism and body composition could affect serum concentrations of IGF-1 and IGFBP-3 and bone (tibiae and mandible) histology and histomorphometry. Twenty-one male weanling Wistar rats (body weight = 38.20 +/- 0.94 g) were randomized to three groups: seven of them were killed at day = 0 (CO, n = 7); control (C, n = 7); and experimental 80 (E80,n = 7). During 4 weeks, C was fed ad libitum with a 1: 1 carbohydrate to fat diet. E80 was being underfed with the same diet by 80% and the followingparameters were measured: weight (Wt) for length (L) ratio z-score; oxygenconsumption (VO2); body composition (BC) by EM-SCAN SA 3000. At t = 28, E80 and C were killed. Serum IGF-1 and IGFBP-3 and bone histology and histomorphometry were performed on C0, E80 and C. E80 showed Wt for L z-score between lean and adequate, a decrease in VO2 according to body proportions, a BC of a delayed puberty individual, IGF-1 and IGFBP-3 decreased by 56 and 53%, respectively. Tibiae's hematopoyetic and adipose bone marrow areas were combined, with sealing trabeculae on metaphyseal areas. This study suggeststhat there is a relationship among growth deceleration in ND rats and structural alterations on tibiae.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:29:54