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Titolo:
Epigenetic reprogramming of the genome - from the germ line to the embryo and back again
Autore:
Arney, KL; Erhardt, S; Drewell, RA; Surani, MA;
Indirizzi:
Wellcome, CRC Inst Canc & Dev Biol, Cambridge CB2 1QR, England Wellcome Cambridge England CB2 1QR Dev Biol, Cambridge CB2 1QR, England
Titolo Testata:
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
fascicolo: 3, volume: 45, anno: 2001,
pagine: 533 - 540
SICI:
0214-6282(2001)45:3<533:EROTG->2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE H19 GENE; DROSOPHILA BITHORAX COMPLEX; IMPRINTING-CONTROL ELEMENT; CHROMATIN DOMAIN BOUNDARY; POLYCOMB-GROUP PROTEIN; DNA METHYLATION; CAENORHABDITIS-ELEGANS; SILENCER ELEMENT; TRANSCRIPTIONAL ACTIVITY; HISTONE DEACETYLATION;
Keywords:
imprinting; epigenetic; reprogramming; germline; preimplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Surani, MA Wellcome, CRC Inst Canc & Dev Biol, Cambridge CB2 1QR, England Wellcome Cambridge England CB2 1QR Cambridge CB2 1QR, England
Citazione:
K.L. Arney et al., "Epigenetic reprogramming of the genome - from the germ line to the embryo and back again", INT J DEV B, 45(3), 2001, pp. 533-540

Abstract

Mammalian parental genomes are not functionally equivalent, and both a maternal and paternal contribution is required for normal development. The differences between the parental genomes are the result of genomic imprinting - a form of gene regulation that results in monoallelic expression of imprinted genes. Cis-regulatory elements at imprinted loci are responsible for directing allele-specific epigenetic marks required for correct gene expression. This cis information must be interpreted at various points in development, including in the germline where existing imprints are erased and reset. Imprints must also be maintained during preimplantation development, whenthe genome undergoes dramatic global epigenetic changes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 18:07:34