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Titolo:
Sodium nitroprusside induces apoptosis of H9C2 cardiac muscle cells in a c-Jun N-terminal kinase-dependent manner
Autore:
Chae, HJ; So, HS; Chae, SW; Park, JS; Kim, MS; Oh, JM; Chung, YT; Yang, SH; Jeong, ET; Kim, HM; Park, RK; Kim, HR;
Indirizzi:
Wonkwang Univ, Sch Dent, Dept Dent Pharmacol, Iskan, Chonbuk, South Korea Wonkwang Univ Iskan Chonbuk South Korea col, Iskan, Chonbuk, South Korea Wonkwang Univ, Sch Dent, Wonkwang Dent Res Inst, Iskan, Chonbuk, South Korea Wonkwang Univ Iskan Chonbuk South Korea nst, Iskan, Chonbuk, South Korea Chonbuk Natl Univ, Dept Pharmacol, Iksan, Chonbuk, South Korea Chonbuk Natl Univ Iksan Chonbuk South Korea Iksan, Chonbuk, South Korea Chonbuk Natl Univ, Inst Cardiovasc Res, Iksan, Chonbuk, South Korea Chonbuk Natl Univ Iksan Chonbuk South Korea Iksan, Chonbuk, South Korea Wonkwang Univ, Coll Pharm, Dept Microbiol, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Coll Pharm, Dept Anat, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Coll Pharm, Sch Med, Dept Internal Med, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Coll Pharm, Dept Oriental Pharmacol, Iksan 570749, Chonbuk,South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 70749, Chonbuk,South Korea
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 5, volume: 1, anno: 2001,
pagine: 967 - 978
SICI:
1567-5769(200105)1:5<967:SNIAOH>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; CONTRACTILE FUNCTION; ALLOGRAFT-REJECTION; ACTIVATION; MYOCYTES; CLONING; PATHWAY; GROWTH; INHIBITION; EXPRESSION;
Keywords:
sodium nitroprusside; H9C2 cells; MAP kinase; cell death;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, HR Wonkwang Univ, Sch Dent, Dept Dent Pharmacol, Iskan, Chonbuk, South Korea Wonkwang Univ Iskan Chonbuk South Korea an, Chonbuk, South Korea
Citazione:
H.J. Chae et al., "Sodium nitroprusside induces apoptosis of H9C2 cardiac muscle cells in a c-Jun N-terminal kinase-dependent manner", INT IMMUNO, 1(5), 2001, pp. 967-978

Abstract

Sodium nitroprusside (SNP) induces apoptosis in H9C2 cardiac muscle cells. Treatment with an exogenous NO donor SNP (2 mM) to H9C2 cells resulted in apoptotic morphological changes; a bright blue-fluorescent condensed nucleiand chromatin fragmentation by fluorescence microscope of Hoechst 33258-staining. The activity of caspase-3 like protease was increased during SNP-induced cell death. However, the activity of caspase-1 like protease was not affected by SNP. Pretreatment with Z-VAD-FMK (a pan-caspase inhibitor) or Ac-DEVD-CHO (a specific caspase-3 inhibitor) abrogated the SNP-induced cell death. SNP markedly activated three MAP kinases (JNK/SAPK, ERK and p38 MAP kinase) in the cardiac muscle cells. In this study, selective inhibition ofthe ERK or p38 MAPK pathway (by PD98059 or SB103580, respectively) had no effect on the extent of SNP-induced apoptosis in cardiac muscle cells. In contrast, inhibition of the JNK pathway by transfection of a dominant negative mutant of JNK markedly reduced the extent of SNP-induced cell death. Taken together, we suggest that JNK/SAPK will be related to SNP-induced apoptosis of H9C2 cardiac muscle cells. (C) 2001 Elsevier Science B.V. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:00:21