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Titolo:
Immunotoxicological investigation of subacute combined exposure by permethrin and the heavy metals arsenic(III) and mercury(II) in rats
Autore:
Institoris, L; Siroki, O; Undeger, U; Basaran, N; Desi, I;
Indirizzi:
Univ Szeged, Fac Med, Dept Publ Hlth, H-6720 Szeged, Hungary Univ Szeged Szeged Hungary H-6720 Dept Publ Hlth, H-6720 Szeged, Hungary Hacettepe Univ, Fac Pharm, Dept Pharmacol Toxicol, TR-06100 Ankara, TurkeyHacettepe Univ Ankara Turkey TR-06100 l Toxicol, TR-06100 Ankara, Turkey
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 5, volume: 1, anno: 2001,
pagine: 925 - 933
SICI:
1567-5769(200105)1:5<925:IIOSCE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
3 GENERATIONS; IMMUNE-RESPONSES; DIMETHOATE; MICE; CYPERMETHRIN; SENSITIVITY; DICHLORVOS; CHEMICALS; TOXICITY; LEAD;
Keywords:
immunotoxicity; arsenic(III); mercury(II); permethrin; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Institoris, L Univ Szeged, Fac Med, Dept Publ Hlth, Dom Ter 10, H-6720 Szeged, Hungary Univ Szeged Dom Ter 10 Szeged Hungary H-6720 zeged, Hungary
Citazione:
L. Institoris et al., "Immunotoxicological investigation of subacute combined exposure by permethrin and the heavy metals arsenic(III) and mercury(II) in rats", INT IMMUNO, 1(5), 2001, pp. 925-933

Abstract

Effects of combined 28 days of oral exposure to the insecticide Permethrin(Pe), alone or in combination with arsenic-III (As) or Hg-II (Hg), were investigated on certain toxicological (body weight, organ weights), haematological (white blood cell (WBC) and red blood cell (RBC) counts, haematocrit (Ht), mean cell volume (MCV). cell content of the femoral bone marrow) and immune function (IgM-PFC, delayed-type hypersensitivity (DTH) reaction) parameters of male Wistar rats. Immunotoxic (H = high) and NOEL (L = low) doses of the three substances were determined in preliminary experiments under identical experimental conditions. In the present study, the immunotoxic dose of Pe (126 mg/kg) was combined with the NOEL dose of As (3.33 mg/kg) or Hg (0.40 mg/kg), and the NOEL dose of Pe (12.6 mg/kg) with the immunotoxic dose of As (13.3 mg/kg) or tig (3.20 mg/kg). A separate group of animals, treated with the appropriate high dose component only, was used as internal control. Significant interactions were observed in the liver weight of the animals treated with Pe(H)-As(L) or As(H)-Pe(L), in the cell content of thefemoral bone marrow in case of Pe(H)-As(L) and Pe(H)-Hg(L) combinations, as well as in the number of PFCs formed from 10(6) spleen cells in the Pe(H)-As(L) and in the maximum of DTH reaction in the Hg(H)-Pe(L) combination. The results show that combined exposures by the investigated substances modify the toxic (including immunotoxic) effects of the single compounds. Thesefindings rise the probability that the interactions observed can also be present in human situations altering the health hazard of this three chemicals. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:20:42