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Titolo:
Comparison of the effect of lidocaine-epinephrine and prilocaine-felypressine to alter macrophage functions
Autore:
Azuma, Y; Ohura, K;
Indirizzi:
Osaka Dent Univ, Dept Pharmacol, Hirakata, Osaka 5731121, Japan Osaka DentUniv Hirakata Osaka Japan 5731121 rakata, Osaka 5731121, Japan
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 5, volume: 1, anno: 2001,
pagine: 911 - 923
SICI:
1567-5769(200105)1:5<911:COTEOL>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; LOCAL-ANESTHETICS; NADPH-OXIDASE; POLYMORPHONUCLEAR LEUKOCYTES; RESPIRATORY BURST; HUMAN NEUTROPHILS; DIVALENT-CATIONS; IMMUNE FUNCTIONS; PHAGOCYTOSIS; ACTIVATION;
Keywords:
lidocaine-epinephrine; prilocaine-felypressine; macrophage; epinephrine; superoxide dismutase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Azuma, Y Osaka Dent Univ, Dept Pharmacol, 8-1 Kuzuhahanazono Cho, Hirakata, Osaka 5731121, Japan Osaka Dent Univ 8-1 Kuzuhahanazono Cho Hirakata Osaka Japan 5731121
Citazione:
Y. Azuma e K. Ohura, "Comparison of the effect of lidocaine-epinephrine and prilocaine-felypressine to alter macrophage functions", INT IMMUNO, 1(5), 2001, pp. 911-923

Abstract

In vitro treatment of macrophages with lidocaine-epinephrine or prilocaine-felypressine resulted in inhibition of their adhesion, chemotaxis and phagocytosis. However, prilocaine-felypressine was a much more potent inhibitorof adhesion and phagocytosis than Lidocaine-epinephrine. On the other hand, lidocaine-epinephrine induced transient potentiation of superoxide anion production by macrophages. while prilocaine-felypressine consistently inhibited this. Moreover. lidocaine-epinephrine and prilocaine-felypressine bothinhibited the production of hydrogen peroxide. In contrast, epinephrine strongly potentiated superoxide anion production, while markedly inhibiting hydrogen peroxide production. This potentiation by epinephrine was not prevented by adrenergic antagonists. In addition, superoxide dismutase potentiated the production of hydrogen peroxide. which was in part prevented by epinephrine. These results suggest that lidocaine-epinephrine and prilocaine-felypressine inhibit adhesion. chemotaxis, phagocytosis, and the production of hydrogen peroxide by macrophages. In addition, lidocaine-epinephrine evidently differs from prilocaine-felypressine regarding the molecular mechanisms underlying the modulation of superoxide anion production by macrophages. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:48:10