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Titolo:
Physical interaction of human papillomavirus virus-like particles with immune cells
Autore:
Da Silva, DM; Velders, MP; Nieland, JD; Schiller, JT; Nickoloff, BJ; Kast, WM;
Indirizzi:
Loyola Univ, Cardinal Bernardin Canc Ctr, Canc Immunol Program, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 c Immunol Program, Maywood, IL 60153 USA Loyola Univ, Dept Microbiol & Immunol, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 crobiol & Immunol, Maywood, IL 60153 USA NIH, Cellular Oncol Lab, Bethesda, MD 20892 USA NIH Bethesda MD USA 20892NIH, Cellular Oncol Lab, Bethesda, MD 20892 USA
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 5, volume: 13, anno: 2001,
pagine: 633 - 641
SICI:
0953-8178(200105)13:5<633:PIOHPV>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
FC-GAMMA-RIII; HUMAN-IMMUNODEFICIENCY-VIRUS; SURFACE HEPARAN-SULFATE; MAJOR CAPSID PROTEIN; HERPES-SIMPLEX VIRUS; ANTIGEN PRESENTATION; SIGNAL-TRANSDUCTION; LANGERHANS CELLS; ALPHA-6 INTEGRIN; IGG FC;
Keywords:
antigen presentation; CD16; Fc receptor; papillomavirus; vaccine; virus-like particles;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Kast, WM Loyola Univ, Cardinal Bernardin Canc Ctr, Canc Immunol Program, 2160 S 1stAve, Maywood, IL 60153 USA Loyola Univ 2160 S 1st Ave Maywood IL USA 60153 ood, IL 60153 USA
Citazione:
D.M. Da Silva et al., "Physical interaction of human papillomavirus virus-like particles with immune cells", INT IMMUNOL, 13(5), 2001, pp. 633-641

Abstract

Human papillomavirus virus-like particles (HPV VLP) and chimeric VLP are immunogens that are able to elicit potent anti-viral/tumor a and T cell responses. To investigate the immunogenicity of VLP, we determined which cells of the immune system are able to bind HPV-16 VLP, VLP were found to bind very well to human and mouse immune cells that expressed markers of antigen-presenting cells (APC) such as MHC class II, CD80 and CD86, including dendritic cells, macrophages and B cells, mAb blocking studies identified Fc gamma RIII (CD16) as one of the molecules to which the VLP can bind both on immune cells and foreskin epithelium. However, transfection of a CD16(-) hell line with CD16 did not confer binding of VLP. Splenocytes from Fc gamma RIII knockout mice Showed a 33% decrease in VLP binding overall and specifically to subsets of APC, These combined data support a role for CD16 as an accessory molecule in an HPV VLP-receptor complex, possibly contributing to the immunogenicity of HPV VLP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 11:45:48