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Titolo:
Role of exhaled nitric oxide in asthma
Autore:
Yates, DH;
Indirizzi:
Univ Sydney, Fac Med, St Leonards, NSW, Australia Univ Sydney St LeonardsNSW Australia c Med, St Leonards, NSW, Australia Royal N Shore Hosp, Dept Resp Med, St Leonards, NSW 2065, Australia Royal N Shore Hosp St Leonards NSW Australia 2065 ds, NSW 2065, Australia
Titolo Testata:
IMMUNOLOGY AND CELL BIOLOGY
fascicolo: 2, volume: 79, anno: 2001,
pagine: 178 - 190
SICI:
0818-9641(200104)79:2<178:ROENOI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY VASCULAR TONE; MILD ASTHMA; L-ARGININE; AIRWAY INFLAMMATION; S-NITROSOTHIOLS; GLUCOCORTICOIDS INHIBIT; ALVEOLAR MACROPHAGES; INHALED BUDESONIDE; ENDOTHELIAL-CELLS; CHILDHOOD ASTHMA;
Keywords:
airway inflammation; asthma; nitric oxide; nitrosothiols;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
126
Recensione:
Indirizzi per estratti:
Indirizzo: Yates, DH Suite 706,26 Ridge St, N Sydney, NSW 2060, Australia Suite 706,26 Ridge St N Sydney NSW Australia 2060 60, Australia
Citazione:
D.H. Yates, "Role of exhaled nitric oxide in asthma", IMM CELL B, 79(2), 2001, pp. 178-190

Abstract

Nitric oxide (NO), an evanescent atmospheric gas, has recently bren discovered to be an important biological mediator in animals and humans. Nitric oxide plays a key role within the lung in the modulation of a rude variety of functions including pulmonary vascular tone. nonadrenergic non-cholinergic (NANC) transmission and modification of the Inflammatory response. Asthmais characterized by chronic airway inflammation and Increased synthesis ofNO and other highly reactive and toxic substances (reactive oxygen species). Pro-inflammatory cytokines such as TNF alpha and IL-1 beta are secreted in asthma and result in inflammatory cell recruitment. but also induce calcium- and calmodulin-independent nitric oxide synthases (iNOS) and perpetuate the inflammatory response within the airways. Nitric oxide is released byseveral pulmonary cells including epithelial cells. eosinophils and macrophages, and NO has been shown to be increased in conditions associated with airway inflammation, such as asthma and viral infections. Nitric oxide can be measured in the expired air of several species. and exhaled NO can now be rapidly and easily measured by the use of chemiluminescence analysers in humans. Exhaled NO is increased in steroid-naive asthmatic subjects and during an asthma exacerbation, although it returns to baseline levels with appropriate anti-inflammatory treatment, and such measurements have been proposed as a simple non-invasive method of measuring airway inflammation in asthma. Here the chemical and biological properties of NO are briefly discussed followed by a summary of the methodological considerations relevant to the measurement of exhaled NO and its role in lung diseases including asthma. The origin of exhaled NO is considered and brief mention made of other potential markers of airway inflammation or oxidant stress in exhaled breath.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:35:22