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Titolo:
Regulation of the inflammatory response in asthma by mast cell products
Autore:
Hart, PH;
Indirizzi:
Flinders Univ S Australia, Sch Med, Dept Microbiol & Infect Dis, Adelaide,SA 5001, Australia Flinders Univ S Australia Adelaide SA Australia 5001 e,SA 5001, Australia
Titolo Testata:
IMMUNOLOGY AND CELL BIOLOGY
fascicolo: 2, volume: 79, anno: 2001,
pagine: 149 - 153
SICI:
0818-9641(200104)79:2<149:ROTIRI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; AIRWAY INFLAMMATION; HISTAMINE-RELEASE; IL-10 PRODUCTION; ANTI-IGE; RECEPTOR; LUNG; ACTIVATION; DISEASE; CHEMOATTRACTANT;
Keywords:
asthma; histamine; IgE; IL-13; mast cells; TNF-alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Hart, PH Flinders Univ S Australia, Sch Med, Dept Microbiol & Infect Dis, GPO Box 2100, Adelaide, SA 5001, Australia Flinders Univ S Australia GPO Box 2100 Adelaide SA Australia 5001
Citazione:
P.H. Hart, "Regulation of the inflammatory response in asthma by mast cell products", IMM CELL B, 79(2), 2001, pp. 149-153

Abstract

In airways, mast cells lie adjacent to nerves, blood vessels and lymphatics, which highlights their pivotal importance in regulating allergic inflammatory processes. In asthma, mast cells are predominantly activated by IgE receptor cross linking. In response to activation, preformed mediators that are stored bound to proteoglycans, for example, TNF-alpha, IL-4, IL-13, histamine, tryptase and chymase, are released. New synthesis of arachidonic acid metabolites (leukotriene C4 (LTC4), leukotriene B4 (LTB4) and prostaglandin D2 (PGD2)) and further cytokines is stimulated. Mediators from degranulating mast cells are critical to the pathology of the asthmatic lung. Mast cell proteases stimulate tissue remodelling, neuropeptide inactivation and enhanced mucus secretion. Histamine stimulates smooth muscle cell contraction, vasodilatation and increased venular permeability and further mucus secretion. Histamine induces IL-16 production by CD8(+) cells and airway epithelial cells; IL-16 is an important early chemotactic factor for CD4(+) lymphocytes. LTC4, LTB4 and PGD2 affect venular permeability and can regulate the activation of immune cells. The best characterized mast cell cytokine inasthmatic inflammation is TNF-alpha, which induces adhesion molecules on endothelial cells and subsequent transmigration of inflammatory leucocytes. IL-13 is critical to development of allergic asthma, although its mode of action is less clear.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:04:44