Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Long-term effects on male reproduction of early exposure to common chemical contaminants in drinking water
Autore:
Veeramachaneni, DNR; Palmer, JS; Amann, RP;
Indirizzi:
Colorado State Univ, Anim Reprod & Biotechnol Lab, Dept Physiol, Coll Vet Med & Biomed Sci, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 Sci, Ft Collins, CO 80523 USA
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 5, volume: 16, anno: 2001,
pagine: 979 - 987
SICI:
0268-1161(200105)16:5<979:LEOMRO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
25 GROUNDWATER CONTAMINANTS; TESTIS; MIXTURE; MICE; RAT; DIFFERENTIATION; DYSFUNCTION; PHYSIOLOGY; TOXICOLOGY; SPERMATIDS;
Keywords:
acrosomal dysgenesis; drinking water pollutants; seminal quality; sexual dysfunction; testicular function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Veeramachaneni, DNR Colorado State Univ, Anim Reprod & Biotechnol Lab, Dept Physiol, Coll Vet Med & Biomed Sci, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 80523 USA
Citazione:
D.N.R. Veeramachaneni et al., "Long-term effects on male reproduction of early exposure to common chemical contaminants in drinking water", HUM REPR, 16(5), 2001, pp. 979-987

Abstract

We evaluated sequelae to early exposure of male rabbits to drinking water containing chemicals typical of ground water near hazardous waste sites. The mixture (p.p.m. at 1x) was 7.75 arsenic, 1.75 chromium, 9.25 lead, 12.5 benzene, 3.75 chloroform, 8.5 phenol and 9.5 trichloroethylene. Dutch-Belteddoes received mixture at 0 x (deionized water; control), 1x or 3x as drinking water from day 20 pregnancy through weaning. Exposure of individual males (7-9/treatment) continued until 15 weeks (adolescence); then, all males received deionized water. At 57-61 weeks of age, ejaculatory capability andseminal, testicular, epididymal and endocrine characteristics were evaluated. At 10 opportunities with a female teaser, all seven control males ejaculated every time, but 12 of the 17 treated males failed to express interest, achieve erection and/or ejaculate on one to five occasions; four of the 12 accomplished ejaculation with a second male teaser, Total spermatozoa/ejaculate and daily sperm production were unaffected. However, treatment caused (P < 0.03) acrosomal dysgenesis and nuclear malformations, Baseline serumconcentrations of LH were lower, but with borderline significance (P = 0.05), Testosterone secretion after exogenous human chorionic gonadotrophin (P< 0.04) was low Thus, even at 45 weeks after last exposure to drinking water pollutants, mating desire/ability, sperm quality, and Leydig cell function were subnormal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:23:30