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Titolo:
Strong hyaluronan expression in the full-thickness rat articular cartilagerepair tissue
Autore:
Lammi, PE; Lammi, MJ; Tammi, RH; Helminen, HJ; Espanha, MM;
Indirizzi:
Univ Kuopio, Dept Anat, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 ept Anat, FIN-70211 Kuopio, Finland Kuopio Univ Hosp, Dept Clin Chem, Kuopio 70211, Finland Kuopio Univ Hosp Kuopio Finland 70211 t Clin Chem, Kuopio 70211, Finland Tech Univ Lisboa, Fac Human Kinet, P-1495688 Lisbon, Portugal Tech Univ Lisboa Lisbon Portugal P-1495688 t, P-1495688 Lisbon, Portugal
Titolo Testata:
HISTOCHEMISTRY AND CELL BIOLOGY
fascicolo: 4, volume: 115, anno: 2001,
pagine: 301 - 308
SICI:
0948-6143(200104)115:4<301:SHEITF>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTINUOUS PASSIVE MOTION; EQUINE CARPUS; BEAGLE DOGS; KNEE-JOINT; DEFECTS; RABBIT; ACID; OSTEOARTHRITIS; EXERCISE; COLLAGEN;
Keywords:
hyaluronan; full-depth lesion; articular cartilage; mesenchymal cells; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Lammi, MJ Univ Kuopio, Dept Anat, POB 1627, FIN-70211 Kuopio, Finland UnivKuopio POB 1627 Kuopio Finland FIN-70211 1 Kuopio, Finland
Citazione:
P.E. Lammi et al., "Strong hyaluronan expression in the full-thickness rat articular cartilagerepair tissue", HISTOCHEM C, 115(4), 2001, pp. 301-308

Abstract

Articular cartilage lesions have a poor capacity to regenerate. In full-depth articular cartilage defects, the repair process involves an ingrowth ofmesenchymal cells from the bone marrow to the injured area, and these cells attempt to restore the lesion with cartilage-like repair tissue. In this study, we investigated histologically the distribution of hyaluronan in therat repair tissue in relation to other glycosaminoglycans. Full-depth lesions were drilled to the weight-bearing region of rat medial femoral condyle. The rats were divided into two groups: intermittent active motion (IAM) and running training (RT) groups. In the RT group, programmed exercise was started 1 week after surgery, while the rats in the IAM group could move freely in their cages. The lesions were investigated 4 and 8 weeks after the surgery. Semiquantitative histological grading showed no significant differences in the repair between the groups. In normal articular cartilage, hyaluronan was stained mainly around chondrocytes. During repair, strong hyaluronan staining was observed in loose mesenchymal tissue, while in the repair area undergoing endochondral ossification, hyaluronan was intensively stained mainly around the hypertrophic chondrocytes. Remarkably strong staining for hyaluronan was noticed in areas of apparent mesenchymal progenitor cellinvasion, the areas being simultaneously devoid of staining for keratan sulphate. In conclusion, hyaluronan is strongly expressed in the early cartilage repair tissue, and its staining intensity and distribution shows very sensitively abnormal articular cartilage structure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 13:13:18