Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Increased concentrations of inflammatory mediators in unstable angina: correlation with serum troponin T
Autore:
Mazzone, A; De Servi, S; Mazzucchelli, I; Bossi, I; Ottini, E; Vezzoli, M; Meloni, F; Lotzinker, M; Mariani, G;
Indirizzi:
Policlin S Matteo, Ist Terapia Med & Nefrol, Pavia, Italy Policlin S Matteo Pavia Italy o, Ist Terapia Med & Nefrol, Pavia, Italy Policlin S Matteo, Dipartimento Cardiol, Pavia, Italy Policlin S Matteo Pavia Italy atteo, Dipartimento Cardiol, Pavia, Italy Policlin S Matteo, Ist Malattie Resp, Pavia, Italy Policlin S Matteo Pavia Italy S Matteo, Ist Malattie Resp, Pavia, Italy Policlin S Matteo, Ist Anal Biochim Clin, Pavia, Italy Policlin S Matteo Pavia Italy tteo, Ist Anal Biochim Clin, Pavia, Italy
Titolo Testata:
HEART
fascicolo: 5, volume: 85, anno: 2001,
pagine: 571 - 575
SICI:
1355-6037(200105)85:5<571:ICOIMI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-REACTIVE PROTEIN; INTERCELLULAR-ADHESION MOLECULE-1; ACUTE MYOCARDIAL-INFARCTION; ACUTE CORONARY SYNDROMES; ISCHEMIC-HEART-DISEASE; PROGNOSTIC VALUE; ENDOTHELIAL-CELLS; NEUTROPHIL; PECTORIS; ACTIVATION;
Keywords:
inflammatory cytokines; troponin T; unstable angina;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: De Servi, S Azienda Ospedaliera Ospedale Civile Legnano, UO Cardiol, I-20025 Legnano, Italy Azienda Ospedaliera Ospedale Civile Legnano Legnano Italy I-20025
Citazione:
A. Mazzone et al., "Increased concentrations of inflammatory mediators in unstable angina: correlation with serum troponin T", HEART, 85(5), 2001, pp. 571-575

Abstract

Objective-To measure plasma interferon gamma, monocyte chemotactic protein-1 (MCP-1), and interleukin 6 and to assess their correlation with cardiac troponin T in unstable angina. Design-Blood sampling in patients undergoing coronary arteriography for known or suspected ischaemic heart disease. Patients-76 patients divided in three groups: 29 with unstable angina (group 1), 28 with stable angina (group 2), and 19 without ischaemic heart disease and with angiographically normal coronary arteries (group 3). Main outcome measures-Plasma interleukin 6, interferon gamma, MCP-I, and troponin T in the three groups of patients. Results-Interleukin 6 was increased in group 1 (median 2.19 (range 0.53-50.84) pg/ml) compared with the control group (1.62 (0.79-3.98) pg/ml) (p < 0.005), whereas interferon gamma was higher in group 1 (range 0-5.51 pg/ml) than in the other two groups (range 0-0.74 pg/ml and 0-0.37 pg/ml; p < 0.005 and p < 0.001, respectively). Patients with unstable angina (group 1) andpositive troponin T had higher concentrations of interferon gamma than those with negative troponin T (0-5.51 pg/ml a 0-0.60 pg/ml, p < 0.001). Plasma MCP-1 was also higher in group I (median 267 (range 6-8670) pg/ml) than in the other two groups (134 (19-890) pg/ml and 84.5 (5-325) pg/ml; p < 0.005 and p < 0.001, respectively), and among group 1 patients with a positive troponin T assay than in those with normal troponin T (531 (14.5-8670) pg/ml a 69 (6-3333) pg/ml; p < 0.01). There was no difference in plasma interleukin 6 in group 1 patients between those with and without raised troponin T. Conclusions-The inflammatory cytokines interferon gamma and MCP-1 are increased in patients with unstable angina, particularly in those with raised concentrations of troponin T, suggesting that they are probably related to myocardial cell damage or to plaque rupture and thrombus formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 06:32:30