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Titolo:
Correlation between high frequency intravascular ultrasound and histomorphology in human coronary arteries
Autore:
Prati, F; Arbustini, E; Labellarte, A; Dal Bello, B; Sommariva, L; Mallus, MT; Pagano, A; Boccanelli, A;
Indirizzi:
S Giovanni Hosp, Catheterisat Lab, I-00165 Rome, Italy S Giovanni Hosp Rome Italy I-00165 Catheterisat Lab, I-00165 Rome, Italy Ist Anat Patol, Pavia, Italy Ist Anat Patol Pavia ItalyIst Anat Patol, Pavia, Italy
Titolo Testata:
HEART
fascicolo: 5, volume: 85, anno: 2001,
pagine: 567 - 570
SICI:
1355-6037(200105)85:5<567:CBHFIU>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACORONARY ULTRASOUND; PLAQUE EROSION; DISEASE; THROMBOSIS; VALIDATION; MORPHOLOGY; INVITRO; LESIONS;
Keywords:
intracoronary ultrasound; atherosclerosis; plaque morphology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Prati, F S Giovanni Hosp, Catheterisat Lab, Via N Piccolomini 34, I-00165 Rome, Italy S Giovanni Hosp Via N Piccolomini 34 Rome Italy I-00165 e, Italy
Citazione:
F. Prati et al., "Correlation between high frequency intravascular ultrasound and histomorphology in human coronary arteries", HEART, 85(5), 2001, pp. 567-570

Abstract

Objective-To test the efficacy of high frequency intravascular ultrasound (IVUS) transducers in identifying lipid/necrotic pools in atherosclerotic plaques. Methods-40 MHz transducers were used for in vitro IVUS assessment of 12 arterial segments (10 coronary and two carotid arteries, dissected from five different necropsy cases). IVUS acquisition was performed at 0.5 mm/s afterligature of the branching points to generate a closed system. Lipid/necrotic areas were defined by IVUS as large echolucent intraplaque areas surrounded by tissue with higher echodensity. To obtain histopathological sectionscorresponding to IVUS cross sections, vessels were divided into consecutive 3 mm long segments using the most distal recorded IVUS image as the starring reference. Samples were then fixed with 10% buffered formalin, processed for histopathological study, serially cut, and stained using the Movat pentacrome method. Results-122 sections were analysed. Lipid pools were observed by histologyin 30 sections (25%). IVUS revealed the presence of lipid pools in 19 of these sections (16%; sensitivity 65%, specificity 95%). Conclusions-In vitro assessment of lipid/necrotic pools with high frequency transducers was achieved with good accuracy. This opens new perspectives for future IVUS characterisation of atherosclerotic plaques.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 20:59:10