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Titolo:
Developmental roles and molecular characterization of a Drosophila homologue of Arabidopsis Argonaute1, the founder of a novel gene superfamily
Autore:
Kataoka, Y; Takeichi, M; Uemura, T;
Indirizzi:
Kyoto Univ, Inst Virus Res, Dept Mol Genet, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Res, Dept Mol Genet, Kyoto 6068507, Japan Kyoto Univ, Sch Sci, Dept Biophys, Sakyo Ku, Kyoto 6068502, Japan Kyoto Univ Kyoto Japan 6068502 t Biophys, Sakyo Ku, Kyoto 6068502, Japan Kyoto Univ, Grad Sch Biostudies, Dept Cell & Dev Biol, Sakyo Ku, Kyoto 6068502, Japan Kyoto Univ Kyoto Japan 6068502 Dev Biol, Sakyo Ku, Kyoto 6068502, Japan
Titolo Testata:
GENES TO CELLS
fascicolo: 4, volume: 6, anno: 2001,
pagine: 313 - 325
SICI:
1356-9597(200104)6:4<313:DRAMCO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-CATENIN; NERVOUS-SYSTEM; CELL DIFFERENTIATION; WINGLESS EXPRESSION; NEUROSPORA-CRASSA; ADHERENS JUNCTION; RNA INTERFERENCE; DISC DEVELOPMENT; GENOME PROJECT; EMBRYONIC CNS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Uemura, T Kyoto Univ, Inst Virus Res, Dept Mol Genet, Kyoto 6068507, JapanKyoto Univ Kyoto Japan 6068507 Mol Genet, Kyoto 6068507, Japan
Citazione:
Y. Kataoka et al., "Developmental roles and molecular characterization of a Drosophila homologue of Arabidopsis Argonaute1, the founder of a novel gene superfamily", GENES CELLS, 6(4), 2001, pp. 313-325

Abstract

Background: Arabidopsis Argonaute1 (AGO1) is the founder of a novel gene superfamily that is conserved from fission yeasts to humans. AGO1, and several other members of this superfamily are necessary for stem cell renewal orRNA interference. However, little has been reported about their roles in animal development or about the molecular activities of any of the members. Results: We have isolated a Drosophila homologue of AGO1, dAGO1, in our attempt to search genetically for regulators of Wingless (Wg) signal transduction. dAGO1 is broadly expressed in the embryo and the imaginal disc. dAGO1over-expression at wing margins suggested that it behaves as a positive regulator in the genetic background employed. Loss-of-function mutations of dAGO1, unexpectedly, did not give typical segment polarity phenotypes of thewg class; instead, dAGO1 maternal and zygotic mutant embryos showed developmental defects, with malformation of the nervous system being the most prominent. The mutant decreased in the numbers of several types of neurones and glia examined. The dAGO1 protein was distributed in the cytoplasm and co-sedimented with poly(U)- or poly(A)-conjugated beads. Conclusion: Our results suggest that the dAGO1 protein exerts its developmental functions by binding to RNA either directly or indirectly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 21:37:49