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Titolo:
Roles of the heat shock transcription factors in regulation of the heat shock response and beyond
Autore:
Pirkkala, L; Nykanen, P; Sistonen, L;
Indirizzi:
Univ Turku, Turku Ctr Biotechnol, Turku 20521, Finland Univ Turku Turku Finland 20521 urku Ctr Biotechnol, Turku 20521, Finland Abo Akad Univ, Dept Biol, SF-20500 Turku, Finland Abo Akad Univ Turku Finland SF-20500 Dept Biol, SF-20500 Turku, Finland
Titolo Testata:
FASEB JOURNAL
fascicolo: 7, volume: 15, anno: 2001,
pagine: 1118 - 1131
SICI:
0892-6638(200105)15:7<1118:ROTHST>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING DOMAIN; EMBRYONAL CARCINOMA-CELLS; UBIQUITIN-PROTEASOME PATHWAY; FACTOR-I; STRESS-RESPONSE; GENE-EXPRESSION; MOLECULAR CHAPERONES; NUCLEAR-LOCALIZATION; NEGATIVE REGULATION; ACTIVATION DOMAIN;
Keywords:
heat shock element; hsps; HSF family; knockout and transgenic HSF models;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
125
Recensione:
Indirizzi per estratti:
Indirizzo: Sistonen, L Univ Turku, Turku Ctr Biotechnol, Tykistokaty 6B, Turku 20521,Finland Univ Turku Tykistokaty 6B Turku Finland 20521 20521, Finland
Citazione:
L. Pirkkala et al., "Roles of the heat shock transcription factors in regulation of the heat shock response and beyond", FASEB J, 15(7), 2001, pp. 1118-1131

Abstract

The heat shock response, characterized by increased expression of heat shock proteins (Hsps) is induced by exposure of cells and tissues to extreme conditions that cause acute or chronic stress. Hsps function as molecular chaperones in regulating cellular homeostasis and promoting survival. If the stress is too severe, a signal that leads to programmed cell death, apoptosis, is activated, thereby providing a finely tuned balance between survivaland death, In addition to extracellular stimuli, several nonstressful conditions induce Hsps during normal cellular growth and development. The enhanced heat shock gene expression in response to various stimuli is regulated by heat shock transcription factors (HSFs), After the discovery of the family of HSFs (i.e., murine and human HSF1, 2, and 4 and a unique avian HSF3),the functional relevance of distinct HSFs is now emerging. HSF1, an HSF prototype, and HSF3 are responsible for heat-induced Hsp expression, whereas HSF2 is refractory to classical stressors, HSF4 is expressed in a tissue-specific manner; similar to HSF1 and HSF2, alternatively spliced isoforms addfurther complexity to its regulation. Recently developed powerful genetic models have provided evidence for both cooperative and specific functions of HSFs that expand beyond the heat shock response. Certain specialized functions of HSFs may even include regulation of novel target genes in responseto distinct stimuli.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:19:25