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Titolo:
Graft location affects functional rescue following RPE cell transplantation in the RCS rat
Autore:
Klassen, H; Whiteley, SJO; Young, MJ; Lund, RD;
Indirizzi:
Inst Ophthalmol, Neural Transplant Program, London EC1V 9EL, England Inst Ophthalmol London England EC1V 9EL rogram, London EC1V 9EL, England Schepens Eye Res Inst, Dept Ophthalmol, Boston, MA 02114 USA Schepens Eye Res Inst Boston MA USA 02114 phthalmol, Boston, MA 02114 USA
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 1, volume: 169, anno: 2001,
pagine: 114 - 121
SICI:
0014-4886(200105)169:1<114:GLAFRF>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PUPILLARY LIGHT REFLEX; RETINAL-PIGMENT EPITHELIUM; OLIVARY PRETECTAL NUCLEUS; FIBROBLAST GROWTH-FACTOR; MACULAR DEGENERATION; RETINITIS-PIGMENTOSA; ROYAL-COLLEGE; SURGEONS RATS; AGE; LUMINANCE;
Keywords:
retinal pigment epithelium; photoreceptor; pupillary light reflex; retinal degeneration; pretectum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Klassen, H Childrens Hosp Orange Cty, 455 S Main St, Orange, CA 92868 USA Childrens Hosp Orange Cty 455 S Main St Orange CA USA 92868 USA
Citazione:
H. Klassen et al., "Graft location affects functional rescue following RPE cell transplantation in the RCS rat", EXP NEUROL, 169(1), 2001, pp. 114-121

Abstract

Photoreceptor (PRC) rescue in the dystrophic Royal College of Surgeons (RCS) rat has been well documented following a variety of interventions. Although the dystrophic process is asymmetric with respect to the horizontal meridian, little attention has been paid to the effect of topographic positionon treatment outcome. In this study, RPE cells from adult congenic nondystrophic animals were injected into the subretinal space of 1-month-old dystrophic RCS rats in either the dorsal or the ventral equatorial region. Animals were followed longitudinally during the degenerative process using the pupillary light reflex (PLR). The parameter of the PLR most sensitive to PRCrescue is latency at low light levels. At 3 months of age this parameter showed statistically better performance (ANOVA, P = 0.016) for eyes with grafts placed dorsally compared to those placed ventrally or untreated controls. There was no treatment effect on amplitude. By 6 months of age the dorsal/ventral disparity in latency was less apparent and amplitude remained equivalent across groups. Late analysis of retinal whole-mounts using RT-97 fluorescent labeling showed extensive irregularities in ventral axonal morphology in all treatment groups. These results indicate that functional rescueof the RCS retina is significantly influenced by the local degenerative timetable. The role of initial local conditions on treatment outcome is worthy of consideration in other models of neuroprotection. (C) 2001 Academic Press.

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Documento generato il 04/04/20 alle ore 09:59:25