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Titolo:
Early and late morphological effects of experimental HPNS - animal model of psychosis?
Autore:
Stumm, G; Geissel, H; Wenzel, J; Mennel, HD;
Indirizzi:
Univ Marburg, Abt Neuropathol, Med Zentrum Pathol, D-35043 Marburg, Germany Univ Marburg Marburg Germany D-35043 um Pathol, D-35043 Marburg, Germany DLR, Inst Luft & Raumfahrt, Cologne, Germany DLR Cologne GermanyDLR, Inst Luft & Raumfahrt, Cologne, Germany
Titolo Testata:
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
fascicolo: 1, volume: 53, anno: 2001,
pagine: 45 - 55
SICI:
0940-2993(200104)53:1<45:EALMEO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-PRESSURE; NERVOUS-SYSTEM; RATS;
Keywords:
HPNS (high pressure neurological syndrome); neuronal and brain damage; dark neurons; morphology of immediate and late HPNS sequelae; animal model of psychosis; high pressure neurological syndrome (HPNS); damage of brain and neurons; neurons, dark; late and immediate sequelae of HPNS; psychosis, animal model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Mennel, HD Univ Marburg, Abt Neuropathol, Med Zentrum Pathol, Baldingerstr, D-35043 Marburg, Germany Univ Marburg Baldingerstr Marburg Germany D-35043 urg, Germany
Citazione:
G. Stumm et al., "Early and late morphological effects of experimental HPNS - animal model of psychosis?", EXP TOX PAT, 53(1), 2001, pp. 45-55

Abstract

The high pressure neurological syndrome (HPNS), a neurological condition during elevated pressure especially in deep diving, has been simulated with experimental animals. Rats were subjected to 61 bars with slow pressure increase and one or two hours constant high pressure; subsequently the pressure was released to sea level within 20 seconds - leading to immediate oxygendepletion and death of animals - or with slow decompression rates allowingsurvival. In all animals, brains and partly c,ther organs were investigated morphologically. In animals sacrificed immediately, subtle changes in different brain regions were found: symmetrical occurrence of dark neurons in the hippocampus formation, cortex and brain stem, reduced expression of tyrosin hydroxylase in the substantia nigra and enhanced expression of Bar protein in some of these regions. The dark neurons were only observed after aldehyde fixation, otherwise the brains were unaltered despite ultrarapid decrease of highly elevated pressure. In animals that were allowed to survive for different time periods, some of these subtle changes were equally noted by light and electron microscopy. Furthermore, the ventricles were enlarged, the astrocytic reaction in the hippocampus increased and some signs of the destruction of the adrenal gland were visible. We conclude, that HPNS leads to minimal changes within the nervous system. The behaviour of animals during pressure was slightly altered, the weightsafter the experiments reduced, but no lasting sequelae were noted. Since both in human and experimental deep diving conditions signs of psychosis were reported, this HPNS model must be considered as a tentative animal model of human psychosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:40:38