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Titolo:
Increased monocyte activation in elderly patients after surgical stress
Autore:
Ono, S; Aosasa, S; Tsujimoto, H; Ueno, C; Mochizuki, H;
Indirizzi:
Natl Def Med Coll, Dept Surg 1, Tokorozawa, Saitama 3598513, Japan Natl Def Med Coll Tokorozawa Saitama Japan 3598513 Saitama 3598513, Japan
Titolo Testata:
EUROPEAN SURGICAL RESEARCH
fascicolo: 1, volume: 33, anno: 2001,
pagine: 33 - 38
SICI:
0014-312X(2001)33:1<33:IMAIEP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY RESPONSE SYNDROME; NECROSIS-FACTOR-ALPHA; ORGAN DYSFUNCTION; LEUKOCYTE ACTIVATION; SERUM INTERLEUKIN-6; HLA-DR; SEVERITY; SURGERY; CELLS; COMPLICATIONS;
Keywords:
surgical stress; monocyte; cytokine; CD11b/CD18; aging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Ono, S Natl Def Med Coll, Dept Surg 1, Namiki 3-2, Tokorozawa, Saitama 3598513, Japan Natl Def Med Coll Namiki 3-2 Tokorozawa Saitama Japan 3598513 Japan
Citazione:
S. Ono et al., "Increased monocyte activation in elderly patients after surgical stress", EUR SURG RE, 33(1), 2001, pp. 33-38

Abstract

Objective: To investigate age-related changes in the host response to surgical stress. The clinical course, serum interleukin-6 (IL-6) levels, monocyte production of tumor necrosis factor-alpha (TNF-alpha), and monocyte expression of CD11b/CD18 were used as markers of the systemic response. Methods: Patients with gastric cancer, undergoing distal gastrectomy were divided into 2 groups: >75 years of age (elderly group) and less than or equal to 75 years of age (young group). Serum IL-6 levels, TNF-a production and CD11b/CD18 expression by monocytes, and the postoperative clinical course were compared between the 2 groups. Results: TNF-alpha production by lipopolysaccharide-stimulated monocytes and CD11b/CD18 expression on monocytes after surgical stress were significantly higher in the elderly than in the young group. Moreover, serum IL-6 levels on the first postoperative day in the elderly group were significantly higher than those in the young group. The incidence and duration of systemic inflammatory response syndrome (SIRS) were significantly greater in the elderly than in the young group. Conclusions: The activation of monocytes and hypercytokinemia occur readily after surgical stress in the elderly and may therefore contribute to SIRS and increased susceptibility to postoperative complications. Copyright (C) 2001 S. KargerAG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:32:59