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Titolo:
Intravenous administration of ecstasy (3,4-methylendioxymethamphetamine) enhances cortical and striatal acetylcholine release in vivo
Autore:
Acquas, E; Marrocu, P; Pisanu, A; Cadoni, C; Zernig, G; Saria, A; Di Chiara, G;
Indirizzi:
Univ Cagliari, Dept Toxicol, I-09126 Cagliari, Italy Univ Cagliari Cagliari Italy I-09126 pt Toxicol, I-09126 Cagliari, Italy CNR, Ctr Neuropharmacol, I-09126 Cagliari, Italy CNR Cagliari Italy I-09126 , Ctr Neuropharmacol, I-09126 Cagliari, Italy Dept Psychiat, Div Neurochem, A-6020 Innsbruck, Austria Dept Psychiat Innsbruck Austria A-6020 rochem, A-6020 Innsbruck, Austria
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 418, anno: 2001,
pagine: 207 - 211
SICI:
0014-2999(20010427)418:3<207:IAOE(E>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT FRONTAL-CORTEX; FREELY-MOVING RATS; DOPAMINERGIC REGULATION; INVIVO MICRODIALYSIS; ENDOGENOUS DOPAMINE; RECEPTOR; MDMA; HIPPOCAMPUS; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; BRAIN;
Keywords:
acetylcholine; (+/-)-3,4-methylendioxymethamphetamine (MDMA ecstasy); microdialysis; prefrontal cortex; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Acquas, E Univ Cagliari, Dept Toxicol, V A Diaz 182, I-09126 Cagliari, Italy Univ Cagliari V A Diaz 182 Cagliari Italy I-09126 gliari, Italy
Citazione:
E. Acquas et al., "Intravenous administration of ecstasy (3,4-methylendioxymethamphetamine) enhances cortical and striatal acetylcholine release in vivo", EUR J PHARM, 418(3), 2001, pp. 207-211

Abstract

The effect of intravenous administration of 3,4-methylendioxymethamphetamine (MDMA), in a range of doses (0.33-3.2 mg/kg) that have been shown to maintain self-administration behaviour in rats, on in vivo acetylcholine release from rat prefrontal cortex and dorsal striatum was studied by means of microdialysis with vertical concentric probes. Intravenous administration ofMDMA dose-dependently increased basal acetylcholine release from the prefrontal cortex to 57 +/- 21%, 98 +/- 20%, 102 +/- 7% and 141 +/- 14% above baseline, at doses of 0.32, 0.64, 1.0 and 3,2 mg/kg, respectively. MDMA also stimulated striatal acetylcholine release at the dose of 3.2 mg/kg i.v. (the maximal increase being 32 +/- 3% above baseline) while at the dose of 1 mg/kg i.v., MDMA failed to affect basal acetylcholine output. Administrationof MDMA also dose-dependently stimulated behaviour. The results of the present study show that MDMA affects measures of central cholinergic neurotransmission in vivo and suggest that at least some of the psychomotor stimulant actions of MDMA might be positively coupled with an increase in prefrontal cortical and striatal acetylcholine release. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 22:41:37