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Titolo:
Effect of dopamine D2/D3 receptor antagonist sulpiride on amphetamine-induced changes in striatal extracellular dopamine
Autore:
Jaworski, JN; Gonzales, RA; Randall, PK;
Indirizzi:
Univ Texas, Coll Pharm, Div Pharmacol & Toxicol, Austin, TX 78712 USA UnivTexas Austin TX USA 78712 Pharmacol & Toxicol, Austin, TX 78712 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 418, anno: 2001,
pagine: 201 - 206
SICI:
0014-2999(20010427)418:3<201:EODDRA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTORECEPTOR ACTIVATION; NUCLEUS-ACCUMBENS; NEUROLEPTIC DRUGS; IN-VIVO; RELEASE; INVIVO; NEURONS; RAT; HALOPERIDOL; MODULATION;
Keywords:
amphetamine; dopamine D2 receptor; sulpiride; dopamine receptor antagonist; microdialysis; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Gonzales, RA Univ Texas, Coll Pharm, Div Pharmacol & Toxicol, Austin, TX 78712 USA Univ Texas Austin TX USA 78712 Toxicol, Austin, TX 78712 USA
Citazione:
J.N. Jaworski et al., "Effect of dopamine D2/D3 receptor antagonist sulpiride on amphetamine-induced changes in striatal extracellular dopamine", EUR J PHARM, 418(3), 2001, pp. 201-206

Abstract

Amphetamine increases extracellular dopamine and induces locomotor and stereotypical behaviors in rats. This study examined the effect of the dopamine D2/D3 receptor antagonist sulpiride (50 mg/kg s.c.) on the dopaminergic response to amphetamine (0.5, 2.0. or 8.0 mg/kg i.p.) in male Sprague-Dawleyrats. Extracellular dopamine in the striatum was monitored using in vivo microdialysis and high performance liquid chromatography with electrochemical detection. Dopamine concentration curves were analyzed using non-linear regression and residual F-testing. Amphetamine enhanced extracellular dopamine in a dose-dependent manner. Sulpiride augmented the increase in dopamineinduced by 0.5 and 2 mg/kg amphetamine by decreasing the rate of dopamine concentration fall off in the extracellular space (P < 0.05). Sulpiride also potentiated the amount of dopamine increased by 8 mg/kg amphetamine. but did so by affecting the maximum concentration achieved (P < 0.05), not the onset or offset rates. We conclude that the primary effect of a dopamine D2/D3 receptor antagonist is a potentiation of the effect of amphetamine on extracellular striatal dopamine levels, which may contribute to the enhancedstereotypic effects observed when paired with amphetamine. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:35:21