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Titolo:
Stimulatory effects of centrally injected kappa-opioid receptor agonists on gastric acid secretion in urethane-anesthetized rats
Autore:
Ishihara, S; Tsuchiya, S; Horie, S; Murayama, T; Watanabe, K;
Indirizzi:
Chiba Univ, Fac Pharmaceut Sci, Chem Pharmacol Lab, Chiba 2638522, Japan Chiba Univ Chiba Japan 2638522 Chem Pharmacol Lab, Chiba 2638522, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 418, anno: 2001,
pagine: 187 - 194
SICI:
0014-2999(20010427)418:3<187:SEOCIK>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGHLY SELECTIVE LIGAND; INHIBITION; MEDIATION; MORPHINE; ENDOTOXIN; BINDING; TRH;
Keywords:
gastric acid secretion; opioid receptor type; central injection; (rat);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Murayama, T Chiba Univ, Fac Pharmaceut Sci, Chem Pharmacol Lab, Chiba 2638522, Japan Chiba Univ Chiba Japan 2638522 col Lab, Chiba 2638522, Japan
Citazione:
S. Ishihara et al., "Stimulatory effects of centrally injected kappa-opioid receptor agonists on gastric acid secretion in urethane-anesthetized rats", EUR J PHARM, 418(3), 2001, pp. 187-194

Abstract

Gastric acid secretion has been proposed to be regulated by opioid receptors in the central nervous system (CNS). However. whether the effect of morphine is stimulatory or inhibitory, and the role of type specificity of opioid receptors have not been established. We investigated the effects of centrally injected opioid receptor agonists on gastric acid secretion in the perfused stomach of urethane-anesthetized rats. Injection of morphine (1-30 mug/rat, mu -opioid receptor agonist) into the fourth cerebroventricle inhibited the secretion stimulated by i.v. injection of 2-deoxy-D-glucose. Morphine itself did not show an inhibitory effect. In contrast, injection of kappa (1)-opioid receptor agonists such as (5 alpha ,7 alpha ,8 beta)-(+)-N-methyl-N-(7-[1-pyrrolidinyl]-1-oxaspiro[4.5]dec-8-yl)benzeneacetamide (U59593, 0.3-3 mug) and (trans)-(+/-)- 3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl]cyclohexyl) benzeneacetamide hydrochloride (U50488H, 10 mug) and the kappa (2)-opioid receptor agonist, bremazocine (3 mug) into the lateral cerebroventricle markedly stimulated secretion. The effect of U59593 was inhibited by naloxone and norbinaltorphimine (an antagonist of kappa -opioid receptors) and in vagotomized rats. [D-Pen(2)-D-Pen(5)]enkephalin (10 mug, delta -opioid receptor agonist) had no effect on secretion. The dual roles of the opioid system in the CNS in gastric acid secretion are discussed. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:13:30