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Titolo:
The noradrenaline-dopamine interaction in the rat medial prefrontal cortexstudied by multi-probe microdialysis
Autore:
Kawahara, H; Kawahara, Y; Westerink, BHC;
Indirizzi:
Kyushu Dent Coll, Dept Dent Anesthesiol, Kitakyushu, Fukuoka 803, Japan Kyushu Dent Coll Kitakyushu Fukuoka Japan 803 akyushu, Fukuoka 803, Japan Kurume Univ, Sch Med, Dept Pharmacol, Kurume, Fukuoka, Japan Kurume Univ Kurume Fukuoka Japan Dept Pharmacol, Kurume, Fukuoka, Japan Univ Groningen, Univ Ctr Pharm, Dept Biomonitoring & Sensoring, Groningen,Netherlands Univ Groningen Groningen Netherlands & Sensoring, Groningen,Netherlands
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 418, anno: 2001,
pagine: 177 - 186
SICI:
0014-2999(20010427)418:3<177:TNIITR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS-COERULEUS; EXTRACELLULAR DOPAMINE; NORADRENERGIC NEURONS; NOREPINEPHRINE; RELEASE; CERULEUS; BRAIN; HIPPOCAMPUS;
Keywords:
noradrenaline; dopamine; cortex, prefrontal; microdialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Westerink, BHC Univ Groningen, Univ Ctr Pharm, Dept Med Chem, Deusinglaan 1, NL-9713 AV Groningen, Netherlands Univ Groningen Deusinglaan 1 Groningen Netherlands NL-9713 AV
Citazione:
H. Kawahara et al., "The noradrenaline-dopamine interaction in the rat medial prefrontal cortexstudied by multi-probe microdialysis", EUR J PHARM, 418(3), 2001, pp. 177-186

Abstract

Multi-probe microdialysis was used to investigate the interaction between the release of noradrenaline and dopamine in the medial prefrontal cortex. Retrograde microdialysis was used to stimulate or inhibit the activity of the locus coeruleus for a restricted period of time, and the response of extracellular noradrenaline and dopamine in the ipsilateral and contralateral medial prefrontal cortex was recorded with microdialysis probes. Infusion of clonidine into the locus coeruleus (100 muM for 45 min) suppressed noradrenaline release and slightly inhibited dopamine release in the ipsilateral medial prefrontal cortex. Application of carbachol to the locus coeruleus (100 muM for 45 min) stimulated both the noradrenaline and dopamine release in the ipsilateral medial prefrontal cortex. No changes were seen in the contralateral medial prefrontal cortex. In the ipsilateral nucleus accumbens,extracellular noradrenaline levels increased, but dopamine levels remainedunchanged. Application to the locus coeruleus (during 10 min) of the glutamate receptor agonists N-methyl-D-aspartate (NMDA) (300 muM) or kainate (100 muM) strongly increased extracellular noradrenaline and dopamine levels in the ipsilateral medial prefrontal cortex. However, in the contralateral probe the release of dopamine (but not of noradrenaline) was also stimulated. Application of carbachol to the locus coeruleus was used as a model to further investigate the presumed noradrenaline-dopamine interaction. In a series of dual-probe experiments, alpha (1)-, alpha (2)-, and beta -adrenoceptor antagonists (prazosin, idazoxan, propranolol) or a reuptake-inhibitor (nomifensine) was administered during carbachol stimulation of the locus coeruleus. Prazosin and propranolol were administered systemically in a dose of3 mg/kg, whereas idazoxan (10 muM) and nomifensine (100 muM) were infused into the medial prefrontal cortex. However, none of these pretreatments modified the effects of the control carbachol-infusions. The results did nor identify a receptor-interaction or a common reuptake site that explained thepresumed interaction between dopamine and noradrenaline in the medial prefrontal cortex. Therefore, the noradrenaline-dopamine interaction hypothesiscould not be confirmed or refuted. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 04:43:42