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Titolo:
TY-12533, a novel Na+/H+ exchange inhibitor, prevents myocardial stunning in dogs
Autore:
Aihara, K; Hisa, H; Sasamori, J; Yoneyama, F; Yamaguchi, F; Satoh, I; Satoh, S;
Indirizzi:
Tohoku Univ, Grad Sch Pharmaceut Sci, Pharmacol Lab, Sendai, Miyagi 9808578, Japan Tohoku Univ Sendai Miyagi Japan 9808578 ab, Sendai, Miyagi 9808578, Japan Toa Eiyo Ltd, Fukushima Res Labs, Drug Res Dept, Fukushima 9600280, Japan Toa Eiyo Ltd Fukushima Japan 9600280 Res Dept, Fukushima 9600280, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 419, anno: 2001,
pagine: 93 - 97
SICI:
0014-2999(20010504)419:1<93:TANNEI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DYSFUNCTION; RECOVERY; ISCHEMIA; INVOLVEMENT; RECEPTORS; ADENOSINE; CHANNELS;
Keywords:
TY-12533; Na+/H+ exchange inhibitor; myocardial wall thickening; myocardial blood flow; myocardial pH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Hisa, H Tohoku Univ, Grad Sch Pharmaceut Sci, Pharmacol Lab, Sendai, Miyagi 9808578, Japan Tohoku Univ Sendai Miyagi Japan 9808578 ai, Miyagi 9808578, Japan
Citazione:
K. Aihara et al., "TY-12533, a novel Na+/H+ exchange inhibitor, prevents myocardial stunning in dogs", EUR J PHARM, 419(1), 2001, pp. 93-97

Abstract

Anesthetized open-chest dogs were subjected to 15-min myocardial ischemia followed by 2-h reperfusion to induce myocardial stunning. A novel Na+/H+ exchange inhibitor 6,7,8,9-tetrahydro-2-methyl-5H-cyclohepta[b]pyridine-3-carbonylguanidine maleate (TY-12533), administered 10 min before or 10 min after start of ischemia (3 mg/kg/10 min, i.v.), did not affect reductions in regional myocardial wall thickening, blood flow and pH during ischemia, butit significantly improved recovery of the wall thickening and blood flow after reperfusion. These results indicate that TY-12533, even when administered during ischemia, could prevent myocardial stunning without affecting myocardial dysfunction or acidosis induced by brief ischemia. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:31:14