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Titolo: Ultrasound-promoted synthesis of 2,3-bis(4-hydroxyphenyl)indole derivatives as inherently fluorescent ligands for the estrogen receptor
Autore: Koulocheri, SD; Haroutounian, SA;
- Indirizzi:
- Univ Agr, Chem Lab, Athens 11855, Greece Univ Agr Athens Greece 11855Univ Agr, Chem Lab, Athens 11855, Greece
- Titolo Testata:
- EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
fascicolo: 9,
,
anno: 2001,
pagine: 1723 - 1729
- SICI:
- 1434-193X(200105):9<1723:USO2D>2.0.ZU;2-L
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- UNSYMMETRICAL NONSTEROIDAL LIGANDS; BINDING ORIENTATION; PHOTOFLUOROGENIC LIGANDS; AFFINITY; 2-ARYLINDENONES; RAT;
- Keywords:
- indoles; cyclization; ultrasound; estrogen receptor;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Physical, Chemical & Earth Sciences
- Citazioni:
- 27
- Recensione:
- Indirizzi per estratti:
- Indirizzo: Haroutounian, SA Univ Agr, Chem Lab, Iera Odos 75, Athens 11855, Greece Univ Agr Iera Odos 75 Athens Greece 11855 11855, Greece
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- Citazione:
- S.D. Koulocheri e S.A. Haroutounian, "Ultrasound-promoted synthesis of 2,3-bis(4-hydroxyphenyl)indole derivatives as inherently fluorescent ligands for the estrogen receptor", EUR J ORG C, (9), 2001, pp. 1723-1729
Abstract
A series of 2,3-bis(4-hydroxyphenyl)indole derivatives 4c-f was prepared by ultrasound-promoted intramolecular cyclodehydration of a polyphosphoric acid solution of alpha -anilinyl-(or 3-anisidyl)desoxyanisoins 2c-f, and their optical spectroscopy and estrogen receptor (ER) binding properties were studied. Compounds 4c-f give intense long-wavelength fluorescent emission, sensitive to solvent polarity and pH. Furthermore, the two indol-6-ols 4e, f display reasonably good binding affinities to ER and appear to be well suited for use as fluorescent probes for the detection of ER in cells.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:20:46