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Titolo:
Ultrasound-promoted synthesis of 2,3-bis(4-hydroxyphenyl)indole derivatives as inherently fluorescent ligands for the estrogen receptor
Autore:
Koulocheri, SD; Haroutounian, SA;
Indirizzi:
Univ Agr, Chem Lab, Athens 11855, Greece Univ Agr Athens Greece 11855Univ Agr, Chem Lab, Athens 11855, Greece
Titolo Testata:
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
fascicolo: 9, , anno: 2001,
pagine: 1723 - 1729
SICI:
1434-193X(200105):9<1723:USO2D>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNSYMMETRICAL NONSTEROIDAL LIGANDS; BINDING ORIENTATION; PHOTOFLUOROGENIC LIGANDS; AFFINITY; 2-ARYLINDENONES; RAT;
Keywords:
indoles; cyclization; ultrasound; estrogen receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Haroutounian, SA Univ Agr, Chem Lab, Iera Odos 75, Athens 11855, Greece Univ Agr Iera Odos 75 Athens Greece 11855 11855, Greece
Citazione:
S.D. Koulocheri e S.A. Haroutounian, "Ultrasound-promoted synthesis of 2,3-bis(4-hydroxyphenyl)indole derivatives as inherently fluorescent ligands for the estrogen receptor", EUR J ORG C, (9), 2001, pp. 1723-1729

Abstract

A series of 2,3-bis(4-hydroxyphenyl)indole derivatives 4c-f was prepared by ultrasound-promoted intramolecular cyclodehydration of a polyphosphoric acid solution of alpha -anilinyl-(or 3-anisidyl)desoxyanisoins 2c-f, and their optical spectroscopy and estrogen receptor (ER) binding properties were studied. Compounds 4c-f give intense long-wavelength fluorescent emission, sensitive to solvent polarity and pH. Furthermore, the two indol-6-ols 4e, f display reasonably good binding affinities to ER and appear to be well suited for use as fluorescent probes for the detection of ER in cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:20:46