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Titolo:
Temporal hypometabolism at the onset of cryptogenic temporal lobe epilepsy
Autore:
Matheja, P; Kuwert, T; Ludemann, P; Weckesser, M; Kellinghaus, C; Schuierer, G; Diehl, B; Ringelstein, EB; Schober, O;
Indirizzi:
Univ Munster, Dept Nucl Med, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 Nucl Med, D-48129 Munster, Germany Univ Munster, Dept Neurol, D-48129 Munster, Germany Univ Munster MunsterGermany D-48129 pt Neurol, D-48129 Munster, Germany Univ Munster, Dept Clin Radiol, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 in Radiol, D-48129 Munster, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 5, volume: 28, anno: 2001,
pagine: 625 - 632
SICI:
0340-6997(200105)28:5<625:THATOO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; DIAGNOSED PARTIAL SEIZURES; FDG-PET; REGIONAL HYPOMETABOLISM; PRESURGICAL EVALUATION; GLUCOSE CONSUMPTION; HIPPOCAMPAL ATROPHY; C-11 FLUMAZENIL; NEURONAL LOSS; BLOOD-FLOW;
Keywords:
temporal lobe epilepsy; fluorine-18 fluorodeoxyglucose; positron emission tomography; glucose consumption;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Matheja, P Univ Munster, Dept Nucl Med, Albert Schweitzer Str 33, D-48129 Munster, Germany Univ Munster Albert Schweitzer Str 33 Munster Germany D-48129
Citazione:
P. Matheja et al., "Temporal hypometabolism at the onset of cryptogenic temporal lobe epilepsy", EUR J NUCL, 28(5), 2001, pp. 625-632

Abstract

Most patients with intractable temporal lobe epilepsy (TLE) exhibit temporal glucose hypometabolism. The reasons for the development of this abnormality are as yet unclear. The current notion is that an initial injury causesseizures, which in turn give rise to hypometabolism. The aim of this studywas to assess whether temporal reductions in glucose metabolism in non-lesional TLE are the result of repeated seizures or whether hypometabolism represents an initial disturbance at the onset of disease. Glucose consumptionwas assessed with fluorine-18 fluorodeoxyglucose positron emission tomography (F-18-FDG PET) in 62 patients with cryptogenic non-refractory TLE in different stages of disease. Twelve subjects without neurological illness served as controls. Patients with onset of epilepsy at least 3 years prior to the PET scan were defined as having chronic TLE. Using this criterion, the whole patient cohort included 27 patients with de novo TLE and 35 patients with chronic TLE. The groups were matched for age and sex. The appearance of high-resolution magnetic resonance images of the brain was unremarkable in all patients. In the total cohort, number, duration and frequency of seizures had a significant relation to the magnitude of hypometabolism. Temporal hypometabolism was exhibited by 26 of the 62 patients (42%), including 8 out of 27 (30%) with newly diagnosed TLE and 18 out of 35 (51%) with chronic TLE. The disturbances were more extensive and more severe in patients with chronic TLE. It is concluded that temporal hypometabolism may already be present at the onset of TLE, but is less frequent and less severe in newly diagnosed than in chronic TLE. The metabolic disturbance correlates with the number of seizures. These findings suggest that an initial dysfunction ispresent in a considerable number of patients and that hypometabolism is worsened by continuing epileptic activity.

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Documento generato il 15/01/21 alle ore 23:18:35