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Titolo:
Lymphangiogenesis and the vascular endothelial growth factor receptor (VEGFR)-3 in gastric cancer
Autore:
Yonemura, Y; Fushida, S; Bando, E; Kinoshita, K; Miwa, K; Endo, Y; Sugiyama, K; Partanen, T; Yamamoto, H; Sasaki, T;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Surg 2, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Kanazawa Univ, Expt Therapeut Canc Res Inst, Kanazawa, Ishikawa 920, JapanKanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Natl Canc Ctr, Res Inst, Div Virol, Chuo Ku, Tokyo 104, Japan Natl Canc Ctr Tokyo Japan 104 Inst, Div Virol, Chuo Ku, Tokyo 104, Japan Univ Helsinki, Haartman Inst, Mol Canc Biol Lab, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 ab, FIN-00014 Helsinki, Finland Kanazawa Univ, Sch Med, Dept Biochem, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan
Titolo Testata:
EUROPEAN JOURNAL OF CANCER
fascicolo: 7, volume: 37, anno: 2001,
pagine: 918 - 923
SICI:
0959-8049(200105)37:7<918:LATVEG>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
VEGF-C; EXPRESSION; ANGIOGENESIS; METASTASIS; INDUCTION; VESSELS; CELLS; MOUSE; KDR;
Keywords:
VTGF-C; VEGFR-3; gastric cancer; Flt4; lymphangiogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Yonemura, Y Kanazawa Univ, Sch Med, Dept Surg 2, Takaramachi 13-1, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Takaramachi 13-1 Kanazawa Ishikawa Japan 920 pan
Citazione:
Y. Yonemura et al., "Lymphangiogenesis and the vascular endothelial growth factor receptor (VEGFR)-3 in gastric cancer", EUR J CANC, 37(7), 2001, pp. 918-923

Abstract

Vascular endothelial growth factor C (VEGF-C) is the only factor known to cause lymphangiogenesis. We studied the correlation between VEGF-C and vascular endothelial growth factor receptor-3 (VEGFR-3) expression of 85 primary gastric cancers by reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry, and the results were correlated with the number of lymphatic vessels, stained with anti-VEGFR-3 antibody. RT-PCR and immunohistology demonstrated that VEGF-C was mainly produced from cancer cells.but not from stromal elements. Morphologically, VEGFR-3 expression was detected in the endothelial cells of the stromal lymphatic vessels. There was a statistically positive correlation between the incidence of VEGF-C and VEGFR-3 mRNA expression in the primary tumours (P=0.0002). The number of VEGFR-3-positive lymphatic vessels in VEGF-C mRNA positive tumours was significantly larger than that in VEGF-C-negative tumours. The number of VEGFR-3-positive vessels in the tumour stroma was closely related to the grade of lymphatic invasion of gastric cancer. These results strongly indicate that VEGF-C may induce the proliferation of lymphatic vessels in the stroma of primary gastric cancer via activation of VEGFR-3, expressed on the endothelial cells of lymphatic vessels. In these circumstances. cancer cells can easilyinvade the lymphatic vessel. because of the increase of the contact pointsof cancer cells with the lymphatic vessels. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 18:44:39