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Titolo:
Long-term chemotherapy of HIV-associated Kaposi's sarcoma with liposomal doxorubicin
Autore:
Hengge, UR; Esser, S; Rudel, HP; Goos, M;
Indirizzi:
Univ Essen, Dept Dermatol Venerol & Allergol, STD Unit, D-45122 Essen, Germany Univ Essen Essen Germany D-45122 ergol, STD Unit, D-45122 Essen, Germany
Titolo Testata:
EUROPEAN JOURNAL OF CANCER
fascicolo: 7, volume: 37, anno: 2001,
pagine: 878 - 883
SICI:
0959-8049(200105)37:7<878:LCOHKS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIRETROVIRAL THERAPY; AIDS; VINCRISTINE; BLEOMYCIN; FAILURE; SAFETY; TRIAL;
Keywords:
Kaposi's sarcoma; pegylated liposomal doxorubicin; HIV RNA; CD4 cells; leucopenia; hepatotoxicity; chemotherapy; HIV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Hengge, UR Univ Essen, Dept Dermatol Venerol & Allergol, STD Unit, Hufelandstr 55, D-45122 Essen, Germany Univ Essen Hufelandstr 55 Essen Germany D-45122 Essen, Germany
Citazione:
U.R. Hengge et al., "Long-term chemotherapy of HIV-associated Kaposi's sarcoma with liposomal doxorubicin", EUR J CANC, 37(7), 2001, pp. 878-883

Abstract

The aim of this study was to examine the outcome. adverse events and clinical complications of long-term chemotherapy with pegylated liposomal doxorubicin (PegLiposomal DOX) for human immunodeficiency virus (HIV)-associated Kaposi's sarcoma (KS) in the pre-highly active antirectroval therapy (HAART) era. A phase II study over a 4-year period in a tertiary care university hospital was carried out. 52 acquired immunodeficiency syndrome (AIDS)-patients with advanced E;S received long-term chemotherapy (71 +/- 51 weeks) with a mean of 22.8 +/- 18.2 cycles and a mean cumulative liposomal doxorubicin dose of 456 +/- 364 mg/m(2) (120-1040 mg/m(2)). Tumour burden, duration and dosage of PegLiposomal DOX, adverse events. opportunistic infections, immunological parameters and HIV load were measured. A complete (10%) or partial response (56%) was achieved while on chemotherapy. 10 patients (19%) showed stable disease. Tumour progression was observed in 8 patients (15%). Importantly chemotherapy with PegLiposomal DOX was also successful after previous cytostatic therapy with bleomycin and vincristine. The most common adverse events included leucopenia, neutropenia, anaemia, and increased liver function tests. 34 patients (65%) developed new opportunistic infections and 29 patients (56%) died during the study period. To conclude, pegylated liposomal doxorubicin is a safe and effective drug for long-term chemotherapy of advanced (AIDS) KS without adverse effects on CD4 cell counts and HIVViral load. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:30:47